397321-54-9

Basic information

• Product Name: 1H-Pyrrole, 2-(4-methylbenzoyl)-1-(phenylsulfonyl)-
• CAS NO: 397321-54-9
• Molecular Formula: C18H15NO3S
• Molecular Weight: 325.388
• Mol File: 397321-54-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 2-(4-methylbenzoyl)-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 2-(4-methylbenzoyl)-1-(phenylsulfonyl)-(397321-54-9)
• EPA Substance Registry System: 1H-Pyrrole, 2-(4-methylbenzoyl)-1-(phenylsulfonyl)-(397321-54-9)

Safety Data

• Hazardous Substances Data: 397321-54-9(Hazardous Substances Data)

Upstream product

• 16851-82-4 N-phenylsulfonylpyrrole 
• 10097-32-2 bromine 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 55895-62-0 2-(4-methylbenzoyl)pyrrole 
• 702688-92-4 (1-but-3-en-1-yl-4-phenyl-1H-imidazol-2-yl)(3-methoxyphenyl)methanone 
• 397323-04-5 {1-[(5-ethoxycarbonyl-3-quinolyl)methyl]-1H-pyrrol-2-yl} (4-methylphenyl) ketone 
• 253120-49-9 methyl 2-amino-3-formylbenzoate 
• 20357-21-5 2-bromo-6-nitrobenzaldehyde 

Relevant articles and documents

NOVEL HETEROARYL DERIVATIVE

A heteroaryl derivative of the formula (1): (wherein Ring Z is an optionally substituted heteroaryl, R1 is a carboxyl group or an alkoxycarbonyl group, etc., W1 and W2 are an optionally substituted lower alkylene, Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene, W3 is a single bond, a lower alkylene, a lower alkenylene, etc., W4 is a single bond, -NR10-, etc., Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl), or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

FIBROSIS INHIBITOR

Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is -CO-, -SO2-, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2):(1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms:(2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.

Pyrrole derivatives

Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 alkylene, etc.; Ar2 is an optionally substituted aryl, etc.; W2 and Ar1 mean the following (1) and (2): (1) W1 is an optionally substituted C1-C4 alkylene, etc.; Ar1 is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar1 is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.