39739-04-3

Basic information

• Product Name: dimethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioate
• CAS NO: 39739-04-3
• Molecular Formula: C₁₅H₁₅NO₆
• Molecular Weight: 305.2827
• Mol File: 39739-04-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 436.8°C at 760 mmHg
• Flash Point: 218°C
• Density: 1.34g/cm³
• Vapor Pressure: 7.84E-08mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: dimethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioate(39739-04-3)
• EPA Substance Registry System: dimethyl 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioate(39739-04-3)

Safety Data

• Hazardous Substances Data: 39739-04-3(Hazardous Substances Data)

Upstream product

• 340-90-9 N-phthaloyl-L-glutamic acid 
• 85-44-9 phthalic anhydride 
• 6525-53-7 L-glutamic acid dimethyl ester 

Relevant articles and documents

THALIDOMIDE ANALOGS

Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.

Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels

1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines reduce the levels of inflammatory cytokines such as TNFα in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3 -yl)-isoindoline.