39745-17-0

Basic information

• Product Name: 2-(3-oxo-1,3-diphenylpropyl)cyclopentanone
• Synonyms: 2-(3-Oxo-1,3-diphenylpropyl)cyclopentanone; cyclopentanone, 2-(3-oxo-1,3-diphenylpropyl)-
• CAS NO: 39745-17-0
• Molecular Formula: C₂₀H₂₀O₂
• Molecular Weight: 292.3716
• Mol File: 39745-17-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 465.2°C at 760 mmHg
• Flash Point: 173°C
• Density: 1.138g/cm³
• Vapor Pressure: 7.85E-09mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 2-(3-oxo-1,3-diphenylpropyl)cyclopentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-oxo-1,3-diphenylpropyl)cyclopentanone(39745-17-0)
• EPA Substance Registry System: 2-(3-oxo-1,3-diphenylpropyl)cyclopentanone(39745-17-0)

Safety Data

• Hazardous Substances Data: 39745-17-0(Hazardous Substances Data)

Usage

Physical state

Yellow to light brown solid

Common uses

Synthesis of pharmaceuticals and fragrances

Chemical structure

Ketone derivative with a cyclopentanone backbone and a 1,3-diphenyl-3-oxopropan-1-yl side chain

Role in organic chemistry

Intermediate in the production of other organic compounds, key component in the formation of various heterocyclic structures

Industry applications

Pharmaceutical, fragrance, and flavor industries due to versatile reactivity and ability to serve as a building block for more complex molecules.

Upstream product

• 94-41-7 benzalacetophenone 
• 109-89-7 diethylamine 
• 120-92-3 cyclopentanone 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 1614-92-2 1-(N-piperidino)cyclopentene 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 

Downstream Products

• 78018-73-2 2,4-diphenyl-6,7-dihidro-5H-cyclopentapyridine 
• 114842-25-0 (+/-)-1c.6ac-dihydroxy-1t.3ξ-diphenyl-(3arH)-octahydro-pentalene 
• 114842-25-0 (+/-)-1t.6ac-dihydroxy-1c.3ξ-diphenyl-(3arH)-octahydro-pentalene 
• 21016-30-8 2,4-Diphenyl-5,6-dihydrocyclopenta pyrylium perchlorate 
• 859954-21-5 2-benzyliden-5-(3-oxo-1,3-diphenyl-propyl)-cyclopentanone 
• 138568-38-4 (2,4-Diphenyl-4a,5,6,7-tetrahydro-4H-cyclopenta[b]pyran-7a-yl)-phosphinic acid methyl ester 
• 138568-40-8 1-Methoxy-1-oxo-2,4-diphenyl-octahydro-1λ⁵-cyclopenta[b]phosphinine-2,7a-diol 
• 54146-77-9 2,4-diphenyl-octahydro-cyclopenta[b]thiopyran 
• 73669-82-6 Trifluoro-acetate2,4-diphenyl-6,7-dihydro-5H-cyclopenta[b]thiopyranylium; 
• 92744-72-4 2,4-Diphenyl-1,9a-trimethylene-4a,9-diaza-1,2,4a,9a-tetrahydrofluorene 
• 92744-82-6 2,9a-Diphenyl-3,4-trimethylene-4a,9-diaza-1,2,4a,9a-tetrahydrofluorene 
• 92744-71-3 2,4-Diphenyl-1,9a-trimethylene-9-oxa-4a-aza-1,2,4a,9a-tetrahydrofluorene 
• 78018-74-3 N-Benzyl-2,4-diphenylcyclopenteno<1,2-b>pyridinium Tetrafluoroborate 

Relevant articles and documents

Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

Direct asymmetric michael additions of ketones to nitroolefins and chalcones catalyzed by a Chiral C2-symmetric pyrrolidine-based tetraamine

C2-Symmetric pyrrolidine-based tetraamine, available from commercially starting materials, showed good catalytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.

Domino products from the reaction of 1,3-diaryl-2-propen-1-ones (chalcones) with cyclopentanone

The simple reaction of chalcones with cyclopentanone in the presence of barium hydroxide furnished complex domino products of the types 4 and 5 along with 1,5-diketones 3. Mechanistic considerations reveal that the bicyclic alcohol 4 was formed by sequent