39751-33-2

Basic information

• Product Name: chloramphenicol glucuronide
• Synonyms: chloramphenicol glucuronide;Chloramphenicol 3-O-β-D-Glucuronide;(2R,3R)-2-[(2,2-dichloroacetyl)aMino]-3-hydroxy-3-(4-nitrophenyl)propyl β-D-Glucopyranosiduronic Acid
• CAS NO: 39751-33-2
• Molecular Formula: C₁₇H₂₀Cl₂N₂O₁₁
• Molecular Weight: 0
• Product Categories: Amines;Aromatics;Chiral Reagents;Glucuronides;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Aromatics, Chiral Reagents, Glucuronides, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 39751-33-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 170-174°C
• Boiling Point: 897.7°C at 760 mmHg
• Flash Point: 496.7°C
• Appearance: /
• Density: 1.71g/cm³
• Vapor Pressure: 1.17E-34mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: chloramphenicol glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: chloramphenicol glucuronide(39751-33-2)
• EPA Substance Registry System: chloramphenicol glucuronide(39751-33-2)

Safety Data

• Hazardous Substances Data: 39751-33-2(Hazardous Substances Data)

Usage

Description

Chloramphenicol glucuronide, also known as the major glucuronide metabolite of Chloramphenicol (C325030), is an off-white solid with unique chemical properties. It is derived from the glucuronidation process of Chloramphenicol, which is an antibiotic used to treat various bacterial infections.

Uses

Used in Pharmaceutical Industry:
Chloramphenicol glucuronide is used as a metabolite in the pharmaceutical industry for its potential role in understanding the metabolism and pharmacokinetics of Chloramphenicol. This knowledge can help in optimizing the drug's efficacy and safety profile.
Used in Research and Development:
In the field of research and development, chloramphenicol glucuronide is utilized as a compound for studying the mechanisms of drug metabolism, particularly glucuronidation. This can contribute to the development of new drugs with improved pharmacological properties and reduced side effects.
Used in Quality Control and Standardization:
Chloramphenicol glucuronide is employed as a reference compound in quality control and standardization processes for Chloramphenicol-containing products. It helps ensure the accuracy and reliability of analytical methods used in the pharmaceutical industry.
Used in Toxicology Studies:
In toxicology, chloramphenicol glucuronide is used as a biomarker to study the potential toxic effects of Chloramphenicol on the body. This can aid in the assessment of drug safety and the establishment of safe dosages for patients.
Used in Drug Metabolism and Pharmacokinetics:
Chloramphenicol glucuronide is used as a model compound in drug metabolism and pharmacokinetics research. It helps researchers understand how drugs are metabolized in the body and how their concentrations change over time, which is crucial for optimizing drug dosages and treatment regimens.

InChI:InChI=1/C17H20Cl2N2O11/c18-14(19)15(26)20-8(9(22)6-1-3-7(4-2-6)21(29)30)5-31-17-12(25)10(23)11(24)13(32-17)16(27)28/h1-4,8-14,17,22-25H,5H2,(H,20,26)(H,27,28)/t8-,9-,10+,11+,12-,13+,17-/m1/s1

Upstream product

• 777038-38-7 α-D-glucuronyl fluoride 
• 56-75-7 chloramphenicol 
• 579-51-1 2,2-dichloro-N-[2-hydroxy-1-hydroxymethyl-2-(4-nitrophenyl)ethyl]acetamide 

Relevant articles and documents

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