39777-72-5

Basic information

• Product Name: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one
• Synonyms: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one
• CAS NO: 39777-72-5
• Molecular Weight: 414.415
• Mol File: 39777-72-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one(39777-72-5)
• EPA Substance Registry System: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one(39777-72-5)

Safety Data

• Hazardous Substances Data: 39777-72-5(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 50-00-0 formaldehyd 
• 117-39-5 quercetol 
• 18003-33-3 3',4',5,6,7-pentahydroxyflavone 

Relevant articles and documents

Mannich aminomethylation of flavonoids and anti-proliferative activity against breast cancer cell

We herein report Mannich aminomethylation of variously structural flavonoids and their biological evaluation against human breast cancer cell. Mannich reaction showed that substitution at C-6 position depends on amine basicity and C-ring feature of flavon

Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

A series of nitrogen-containing flavonoid analogues were designed and synthesized by Mannich reaction, and screened for the inhibitory activities of cyclin-dependent kinases using a FRET-based biochemical assay method. The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities. 5,6,7-Trihydroxy-8-(dimethylaminomethyl)-2-phenyl-4H-chromen-4-one 3a, 5,6,7-trihydroxy-8-(pyrrolid inylmethyl)-2-phenyl-4H-chromen-4-one 3b, and 5,6,7-trihydroxy-8-(piperidinylmethyl)-2-phenyl-4H-chromen-4-one 3c (IC50 1.05-1.28 μM) were about sixfold more potent than baicalein 2 (IC50 6.53 μM). 5,6,7-Trihydroxy-8-(morpholinomethyl)-2-phenyl-4H-chromen-4-one 3d, 5,6,7-trihydroxy-8-(thiomorpholinomethy)-2-phenyl-4H-chrom en-4-one 3e, and 5,6,7-trihydroxy-8-(4-methylpiperazinylmethyl)-2-phenyl-4H-chromen-4-one 3f (IC50 0.27-0.38 μM) were about 20-fold more potent than baicalein, and were at the same level as flavopiridol (IC50 0.33 μM).