39791-97-4

Basic information

• Product Name: 1H-Benzimidazole,2-chloro-1,5,6-trimethyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-chloro-1,5,6-trimethyl-(9CI)
• CAS NO: 39791-97-4
• Molecular Formula: C₁₀H₁₁ClN₂
• Molecular Weight: 194.66074
• Product Categories: BENZIMIDAZOLE
• Mol File: 39791-97-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole,2-chloro-1,5,6-trimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-chloro-1,5,6-trimethyl-(9CI)(39791-97-4)
• EPA Substance Registry System: 1H-Benzimidazole,2-chloro-1,5,6-trimethyl-(9CI)(39791-97-4)

Safety Data

• Hazardous Substances Data: 39791-97-4(Hazardous Substances Data)

Upstream product

• 39791-96-3 2-chloro-5,6-dimethyl-1H-benzo[d]imidazole 
• 74-88-4 methyl iodide 
• 2033-30-9 NSC 163165 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 

Relevant articles and documents

4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists

A series of 4-(2-pyridyl)piperazine-1-benzimidazole analogues based on compound 1 was synthesized and evaluated for TRPV1 antagonist activity in capsaicin-induced (CAP) and pH 5.5-induced (pH) FLIPR assays in a human TRPV1-expressing HEK293 cell line. Potent TRPV1 antagonists were identified through SAR studies. From these studies, several antagonists were found, with IC50 values ranging from 32 nM to ～5000 nM. Among these, 11 [IC50 = 90 nM (CAP) and 104 nM (pH)] was further evaluated and found to be orally available in rats (F% = 19.7).