39794-77-9

Basic information

• Product Name: 2-(p-Toluenesulfonyloxy)acetic Acid
• Synonyms: 2-(p-Toluenesulfonyloxy)acetic Acid;Tosylglycolic Acid;2-(tosyloxy)acetic acid
• CAS NO: 39794-77-9
• Molecular Formula: C₉H₁₀O₅S
• Molecular Weight: 230.2377
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 39794-77-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 138.0 to 142.0 °C
• Boiling Point: 424.3°C at 760 mmHg
• Flash Point: 210.4°C
• Appearance: /
• Density: 1.395g/cm³
• Vapor Pressure: 5.91E-08mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 2.02±0.10(Predicted)
• CAS DataBase Reference: 2-(p-Toluenesulfonyloxy)acetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Toluenesulfonyloxy)acetic Acid(39794-77-9)
• EPA Substance Registry System: 2-(p-Toluenesulfonyloxy)acetic Acid(39794-77-9)

Safety Data

• Hazardous Substances Data: 39794-77-9(Hazardous Substances Data)

Usage

Uses

An intermediate of Cefmetazole (C242850).

InChI:InChI=1/C9H10O5S/c1-7-2-4-8(5-3-7)15(12,13)14-6-9(10)11/h2-5H,6H2,1H3,(H,10,11)

Upstream product

• 50-00-0 formaldehyd 
• 151-50-8 potassium cyanide 
• 98-59-9 p-toluenesulfonyl chloride 
• 79-14-1 glycolic Acid 
• 39794-75-7 ethyl α-p-toluenesulfonyloxyacetate 
• 64-69-7 Iodoacetic acid 
• 16836-95-6 silver(I) 4-methylbenzenesulfonate 

Downstream Products

• 76273-02-4 (Toluene-4-sulfonyloxy)-acetic acid quinolin-8-yl ester 
• 76273-08-0 7-tosyloxyacetamido-3-deacetoxycephalosporanic acid 
• 1334484-14-8 2-((2,5-dimethoxybenzyl)(2-phenoxyphenyl)amino)-2-oxoethyl-4-methylbenzenesulfonate 
• 959119-78-9 4-(2-(tosyloxy)acetamido)benzoic acid 
• 501919-59-1 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid 
• 158818-29-2 N-phenyl-O-tosylglycolamide 

Relevant articles and documents

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Synthesis of [11C]PBR06 and [18F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)

The translocator protein 18 kDa (TSPO) is an attractive target for molecular imaging of neuroinflammation and tumor progression. [ 18F]PBR06, a fluorine-18 labeled form of PBR06, is a promising PET TSPO radioligand originally developed at NIMH.

SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY

The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growthinvitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.