39806-89-8

Basic information

• Product Name: 4-ethynyl-1-Methyl-1-H-pyrazole
• Synonyms: 4-ethynyl-1-Methyl-1-H-pyrazole;1-Methyl-4-ethynyl-1H-pyrazole;EOS-61650;4-ethynyl-1-methylpyrazole
• CAS NO: 39806-89-8
• Molecular Formula: C₆H₆N₂
• Molecular Weight: 106.12524
• Mol File: 39806-89-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 181.7±13.0 °C(Predicted)
• Appearance: /
• Density: 0.93±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0?+-.0.10(Predicted)
• CAS DataBase Reference: 4-ethynyl-1-Methyl-1-H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethynyl-1-Methyl-1-H-pyrazole(39806-89-8)
• EPA Substance Registry System: 4-ethynyl-1-Methyl-1-H-pyrazole(39806-89-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 39806-89-8(Hazardous Substances Data)

Usage

General Description

4-Ethynyl-1-Methyl-1-H-pyrazole is a chemical compound belonging to the pyrazole family, characterized by its high nitrogen content. It has a molecular formula of C6H6N2, indicating that it contains six carbon atoms, six hydrogen atoms, and two nitrogen atoms. As it features an alkynyl group (ethynyl), it may possess interesting attributes, potentially making it useful in the fields of pharmaceuticals and materials science, though specific applications have not been extensively documented. As with other chemicals, proper handling and storage are necessary, and further research may be necessary to determine its properties and uses more accurately.

Upstream product

• 74-88-4 methyl iodide 
• 1201657-09-1 1-methyl-4-((trimethylsilyl)ethynyl)-1H-pyrazole 
• 57121-49-0 4-ethynyl-1H-pyrazole 
• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 905752-04-7 4-(2-N-acetamino-4-methoxy-phenylethynyl)-1-methyl-1H-pyrazole 
• 905752-14-9 4-(2,4-dimethoxy-3-fluoro-phenylethynyl)-1-methyl-1H-pyrazole 
• 1033610-49-9 3,5-dimethoxy-4-(4-methoxy-benzyloxy)-2-(1-methyl-1H-pyrazol-4-ylethynyl)-pyridine 
• 1400287-21-9 6-bromo-1-(cyclohexylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine 
• 1400287-36-6 6-bromo-1-(4-fluorobenzyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine 
• 1400287-52-6 tert-butyl-6-(4-((bis(tert-butoxycarbonyl)amino)methyl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1400284-64-1 tert-butyl 6-(2-methoxy-4-(1-methylpiperidin-4-ylcarbamoyl)phenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1400285-25-7 3-chloro-4-(1-(cyclopentylmethyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)-N,N-dimethylbenzamide 
• 1400285-73-5 3-methoxy-4-((2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide 
• 1400285-21-3 tert-butyl 6-(2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1400285-84-8 N-(2-chlorophenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine 
• 1400285-89-3 3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide 
• 1400285-22-4 tert-butyl-6-(4-(dimethylcarbamoyl)-2-methoxyphenylamino)-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1400285-79-1 3-chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzenesulfonamide 

Relevant articles and documents

Visible-Light-Induced [4+2] Annulation of Thiophenes and Alkynes to Construct Benzene Rings

The [4+2] annulation represents an elegant and versatile synthetic protocol for the construction of benzene rings. Herein, a strategy for visible-light induced [4+2] annulation of thiophenes and alkynes, to afford benzene rings, is presented. Under simple and mild reaction conditions, the ready availability and structural diversity of thiophenes and alkynes permit the facile synthesis of several substituted aromatic rings. Valuable drugs and amino acids are also well tolerated. Moreover, DFT calculations explain the high regioselectivity of the reaction.

COMPOUNDS, DEVICES, AND USES THEREOF

The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.