398144-10-0

Basic information

• Product Name: Benzenamine, 4-butyl-N,2-dimethyl-
• CAS NO: 398144-10-0
• Molecular Formula: C12H19N
• Molecular Weight: 177.29
• Mol File: 398144-10-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-butyl-N,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-butyl-N,2-dimethyl-(398144-10-0)
• EPA Substance Registry System: Benzenamine, 4-butyl-N,2-dimethyl-(398144-10-0)

Safety Data

• Hazardous Substances Data: 398144-10-0(Hazardous Substances Data)

Upstream product

• 72072-16-3 4-butyl-2-methyl-aniline 

Relevant articles and documents

Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.

N-(4-Butyl-2-methylphenyl)-N'-hydroxyformamidine (HET0016) was evaluated as the first potent and selective inhibitor of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) synthase. The IC(50) value of HET0016 for the production of 20-HETE from arachidonic acid (AA) by human renal microsomes was 8.9+/-2.7 nM, with over 200 times the selectivity of xenobiotic-metabolizing cytochrome P450 enzymes. An examination of the structure-activity relationship revealed that the unsubstituted hydroxyformamidine moiety and the substituent at the para-position of the N-hydroxyformamidine moiety are necessary for the potent activity of HET0016.