39858-87-2

Basic information

• Product Name: 2,2'-Bi(5-methoxypyridine)
• Synonyms: 2,2'-Bi(5-methoxypyridine);5,5'-Dimethoxy-2,2'-bipyridine
• CAS NO: 39858-87-2
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23588
• Mol File: 39858-87-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-133 °C(Solv: hexane (110-54-3))
• Boiling Point: 361.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.143±0.06 g/cm3(Predicted)
• PKA: 3.37±0.20(Predicted)
• CAS DataBase Reference: 2,2'-Bi(5-methoxypyridine)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-Bi(5-methoxypyridine)(39858-87-2)
• EPA Substance Registry System: 2,2'-Bi(5-methoxypyridine)(39858-87-2)

Safety Data

• Hazardous Substances Data: 39858-87-2(Hazardous Substances Data)

Usage

General Description

2,2'-Bi(5-methoxypyridine) is a chemical compound that consists of two 5-methoxypyridine molecules linked together by a biaryl bond. 2,2'-Bi(5-methoxypyridine) is often used as a ligand in organometallic chemistry and catalysis. It has been shown to be effective in promoting various reactions, including C-C bond formation and cross-coupling reactions. Additionally, 2,2'-Bi(5-methoxypyridine) has been studied for its potential use in the synthesis of pharmaceutical drugs and other organic chemicals. Its unique structure and reactivity make it a valuable tool for researchers and practitioners in the field of chemical synthesis and catalysis.

Upstream product

• 105170-27-2 2-bromo-5-methoxypyridine 
• 139585-48-1 2-chloro-5-methoxypyridine 

Downstream Products

• 2326-78-5 5,5'-dihydroxy-2,2'-bipyridyl 

Relevant articles and documents

Synthesis of heteroleptic phosphine-copper(i) complexes: Fluorescence sensing and catalytic properties

Heteroleptic copper(i)-phosphine complexes have attracted considerable attention because of their diverse structures, and photophysical and catalytic properties. In this work, a series of heteroleptic diimine-diphosphine Cu(i) complexes (C1-C10) were synthesized quantitively using the designed bipyridine (L1-L4) and bidentate polyphosphine (L5-L8) as functional ligands. These mixed ligand-copper(i) complexes were fully characterized by 1H and 13C NMR spectroscopy, electrospray ionization mass spectrometry (ESI-MS) and elemental analysis. The detailed structures of complexes C1, C2, C5, C6, C9 and C10 were confirmed by single-crystal X-ray diffraction analysis. Moreover, these phosphine-Cu(i) complexes exhibited intense emissions either in the solid state or in solution under UV light excitation. The emissive complexes C1-C4 displayed highly sensitive luminescence sensing towards silver ions in a quenching fashion (turn-off). Furthermore, all the phosphine-protected copper(i) complexes exhibited high catalytic activity towards azide-alkyne cycloaddition (CuAAC) in water.

Reductive couplings of 2-halopyridines without external ligand: Phosphine-free nickel-catalyzed synthesis of symmetrical and unsymmetrical 2,2'-bipyridines

An unexpectedly facile synthetic approach for symmetrical and unsymmetrical 2,2'-bipyridines through the Ni-catalyzed reductive couplings of 2-halopyridines was developed. The couplings were efficiently catalyzed by 5 mol % of NiCl2.6H2O without the use of external ligands. A variety of 2,2'-bipyridines including caerulomycin F have been efficiently synthesized.