39876-23-8

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-
• Synonyms: 4-Hydroxy-6-methoxy-3-phenyl-cumarin;4-hydroxy-6-methoxy-3-phenylcoumarin;2H-1-Benzopyran-2-one,4-hydroxy-6-methoxy-3-phenyl;2-hydroxy-6-methoxy-3-phenylchromen-4-one;4-hydroxy-6-methoxy-3-phenyl-2H-chromen-2-one;6-methoxy-3-phenyl-4-hydroxy-coumarin;4-hydroxy-6-methoxy-3-phenyl-1-benzopyran-2-one
• CAS NO: 39876-23-8
• Molecular Formula: C16H12O4
• Molecular Weight: 268.26400
• Mol File: 39876-23-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-(39876-23-8)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 4-hydroxy-6-methoxy-3-phenyl-(39876-23-8)

Safety Data

• Hazardous Substances Data: 39876-23-8(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 83-13-6 diethyl 2-phenylmalonate 
• 13252-84-1 4-hydroxy-6-methoxycoumarin 
• 3076-54-8 phenyllead(IV) triacetate 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 37434-59-6 dimethyl 2-phenylmalonate 

Downstream Products

• 132593-80-7 4-acetoxy-6-methoxy-3-phenyl-coumarin 
• 64555-58-4 6-methoxy-4-(2-morpholin-4-yl-ethoxy)-3-phenyl-chromen-2-one 

Relevant articles and documents

3-phenylcoumarins as inhibitors of HIV-1 replication

We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κB inhibition, four resulted Tat antagonists and three of them showed both activities. Three compounds inhibited HIV replication with IC50 values 25 μM. The antiviral effect of the 4-hydroxycoumarin derivative 19 correlates with its specific inhibition of Tat functions, while compound 8, 3-(2-chlorophenyl) coumarin, seems to act through a mechanism unrelated to the molecular targets considered in this research.

Application of Aryllead(IV) Derivatives to the Preparation of 3-Aryl-4-hydroxy-1-benzopyran-2-ones

Aryllead triacetates are chemoselective and regioselective reagents for the preparation of 3-aryl-4-hydroxy-1-benzopyran-2-ones in good to excellent yields by C-3 arylation of the preformed 4-hydroxy-1-benzopyran-2-one ring.This approach was applied to th