3989-47-7

Basic information

• Product Name: Methanesulfonamide,N-2-naphthalenyl-
• Synonyms: Methanesulfonamide,N-2-naphthalenyl-
• CAS NO: 3989-47-7
• Molecular Formula: C₁₁H₁₁NO₂S
• Molecular Weight: 221.27554
• Mol File: 3989-47-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methanesulfonamide,N-2-naphthalenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide,N-2-naphthalenyl-(3989-47-7)
• EPA Substance Registry System: Methanesulfonamide,N-2-naphthalenyl-(3989-47-7)

Safety Data

• Hazardous Substances Data: 3989-47-7(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 91-59-8 naphthalen-2-ylamine 
• 32316-92-0 naphthalene-2-boronic acid 
• 624-90-8 Methanesulfonyl azide 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 7499-66-3 6-Bromonaphthalen-2-amine 
• 1132940-86-3 N-(6-bromonaphthalen-2-yl)-methanesulfonamide 
• 73183-34-3 bis(pinacol)diborane 
• 133277-09-5 6-bromo-2-oximino-1,2,3,4-tetrahydronaphthalene 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 4133-35-1 6-bromo-2-tetralone 

Downstream Products

• 1454880-62-6 N-(1-(2,5-cimethylphenyl)naphthalen-2-yl)methanesulfonamide 
• 1454880-68-2 1-(2,5-bimethylphenyl)naphthalen-2-amine 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Metal-free synthesis of 2-aminonaphthalenes by intramolecular transannulation of 1-sulfonyl-4-(2-alkenylphenyl)-1,2,3-triazoles

A facile metal-free synthesis of naphthalenes by intramolecular transannulation of 1-sulfonyl-4-(2-alkenylphenyl)-1,2,3-triazoles was realized. The in situ formed ketenimine was proposed as the key intermediate, and the desired 2-aminonaphthalenes were generated in up to 87% yield in refluxing 1,2-dichloroethane without any catalyst or additive.

A convenient reductive deamination (hydrodeamination) of aromatic amines

Reductive deamination (hydrodeamination) of aromatic amines can be conveniently carried out by amination of the corresponding arylamine methanesulfonamides using chloroamine under alkaline conditions. The intermediate aryl methanesulfonylhydrazines directly eliminate methanesulfinic acid, affording diazenes which extrude nitrogen affording the desired deaminated products. Both sulfonamide formation and reduction reactions occur in high yield and are compatible with a variety of functional groups.