39911-06-3

Basic information

• Product Name: 2'-(1-Piperidinyl)acetophenone
• Synonyms: 2'-(1-Piperidinyl)acetophenone;1-(2-(Piperidin-1-yl)phenyl)ethanone
• CAS NO: 39911-06-3
• Molecular Weight: 203.284
• Mol File: 39911-06-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2'-(1-Piperidinyl)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(1-Piperidinyl)acetophenone(39911-06-3)
• EPA Substance Registry System: 2'-(1-Piperidinyl)acetophenone(39911-06-3)

Safety Data

• Hazardous Substances Data: 39911-06-3(Hazardous Substances Data)

Usage

General Description

2'-(1-Piperidinyl)acetophenone is a chemical compound with the molecular formula C14H17NO. It is a derivative of acetophenone, containing a piperidine ring substituted at the 1-position. 2'-(1-Piperidinyl)acetophenone is commonly used in organic synthesis and pharmaceutical research as a building block for various drugs and compounds. It has been studied for its potential pharmacological activities, including its ability to interact with neurotransmitter receptors and its potential as an analgesic or sedative. Additionally, it has been investigated for its potential role in the treatment of various neurological disorders. However, further research is needed to fully understand its pharmacological properties and potential therapeutic applications.

Upstream product

• 110-89-4 piperidine 
• 98-86-2 acetophenone 
• 1352619-50-1 C₁₄H₂₀N₂O 
• 2156-71-0 N-chloropiperidine 
• 3376-33-8 O-methyl acetophenone oxime 
• 445-27-2 2'-Fluoroacetophenone 

Downstream Products

• 117607-69-9 2-{1'-[2'-(piperidin-1''-yl)phenyl]ethylidene}propanedinitrile 
• 70243-93-5 3,4,4a,5-tetrahydro-1H-pyrido[1,2-a]quinolin-6(2H)-one 
• 70243-94-6 1-(2-acetylphenyl)piperidin-2-one 
• 78648-37-0 1-(2-Piperidinophenyl)-ethanol 
• 149704-67-6 2'-(4-Hydroxypiperidino)acetophenon 

Relevant articles and documents

Diastereoselective synthesis of dihydro-quinolin-4-ones by a borane-catalyzed redox-neutral endo-1,7-hydride shift

The borane-catalyzed synthesis of dihydroquinoline-4-ones is developed. The amino-substituted chalcones undergo a 1,7-hydride shift upon Lewis acid activation to form a zwitterionic iminium enolate, which collapses to the dihydroquinoline-4-one scaffold.

Achieving Site Selectivity in Metal-Catalyzed Electron-Rich Carbene Transfer Reactions from N-Tosylhydrazones

Catalyst control of the site-selectivity of electron-rich alkyl, aryl disubstituted carbenes generated in situ from o-alkenyl-substituted N-tosylhydrazones was achieved in this study. Exposure of these substrates to copper iodide triggered the formation of α-alkoxy 2H-naphthalenones. This investigation established that changing the catalyst to a rhodium(II) carboxylate turned off cyclization and migration of the electron-rich metal carbene with the β-carboxylate and turned on allylic C-H bond functionalization to diastereoselectively afford 1H-indenes. Examination of the scope of this reaction revealed that ethereal, aminomethylene, and unactivated 2° C-H bonds could be functionalized.

Unprecedented construction of C=C double bonds via Ir-catalyzed dehydrogenative and dehydrative cross-couplings

Unprecedented constructions of C=C double bonds have been achieved by Ir-catalyzed intramolecular dehydrogenative and dehydrative cross-coupling of tertiary amines and ketones. The reactions are proposed to proceed via an Ir-mediated C-H activation mechan