39953-63-4

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2-ethylphenyl)-
• CAS NO: 39953-63-4
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• Mol File: 39953-63-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-ethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-ethylphenyl)-(39953-63-4)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-ethylphenyl)-(39953-63-4)

Safety Data

• Hazardous Substances Data: 39953-63-4(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 578-54-1 ortho-ethylaniline 
• 136918-14-4 phthalimide 
• 100-41-4 ethylbenzene 
• 19336-72-2 C₁₆H₁₅NO₃ 

Downstream Products

• 1875-48-5 N-aminophthalamide 
• 578-54-1 ortho-ethylaniline 
• 524-38-9 N-hydroxyphthalimide 
• 550-44-7 N-methylphthalimide 

Relevant articles and documents

Hypolipidemic Activity of Phthalimide Derivatives. 2. N-Phenylphthalimide and Derivatives

A series of substituted N-phenylphthalimide derivatives was synthesized and examined for their ability to lower serum cholesterol and triglyceride levels in mice at 20 (mg/kg)/day, ip.Of the newly synthesized compounds, the most potent compound, o-(N-phthalimido)acetophenone, lowered serum cholesterol 57percent after 16 days and lowered serum triglyceride levels 44percent after 14 days. o-(N-Phthalimido)acetophenone was observed to be active in both normogenic (normal blood lipids levels) and hyperlipidemic mice and normogenic rats.In the latter, the reduction of serum lipids was reversible.The mode of action of this compound appeared to be multiple, including blockage of the de novo synthesis of lipids and acceleration of the excretion of lipids.The lipoprotein fractions of rat blood were reduced significantly in cholesterol, triglyceride, and neutral lipid content after 14 days treatment with o-(N-phthalimido)acetophenone.

Aza-DielsAlder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

The synthesis of 5-substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)- ones via [4 + 2] imino-DielsAlder cyclization from N-aryl-3- hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2-substituted-aryl)-3- hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl)isoindolin-1-one analogues indicating steric hinderance as the cause of deviation. The probable mechanism of the reaction based on the results from X-ray crystallography and molecular modelling is discussed.