399559-57-0Relevant articles and documents
Barbier-type diastereoselective allylation of α-amino aldehydes with an enantiopure 2-sulfinylallyl building block
Marquez, Francesc,Montoro, Raul,Llebaria, Amadeu,Lago, Elena,Molins, Elies,Delgado, Antonio
, p. 308 - 311 (2002)
An optimized procedure for the diastereoselective allylation under aqueous Barbier conditions of a series of α-amino aldehydes with our new chiral building block (Ss)-3-chloro-2-(p-tolylsulfinyl)-1-propene [(Ss)-1a] to afford enantiomerically pure sulfinylamino alcohols in good yields and diastereoselectivites is reported. High levels of diastereoinduction can be achieved from α-amino aldehydes configurationally related to natural α-amino acids.