39964-84-6Relevant articles and documents
Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors
Qian, Yimin,Ahmad, Mushtaq,Chen, Shaoqing,Gillespie, Paul,Le, Nam,Mennona, Frank,Mischke, Steven,So, Sung-Sau,Wang, Hong,Burghardt Charles,Tannu, Shahid,Conde-Knape, Karin,Kochan, Jarema,Bolin, David
, p. 6264 - 6269 (2011)
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7- dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class o
Improved procedures for large preperation of 6- and 7-oxy-substituted isoquinolines and a convenient work-up protocol for titanium supported reactions
Kucznierz, Ralf,Dickhaut, Joachim,Leinert, Herbert,Von Der Saal, Wolfgang
, p. 1617 - 1625 (2007/10/03)
Improved procedures for large scale preparation of oxy-substituted isoquinolines are reported. Moreover, a simple and convenient protocol for alkaline work-up of titanium containing reaction mixtures is given, which is expected to be of general interest even for reactions on a technical scale.
Regioselectivity in the Synthesis of Isoquinolines with Methoxy Activating Groups
Euerby, Melvin R.,Waigh, Roger D.
, p. 501 - 526 (2007/10/02)
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