39965-81-6

Basic information

• Product Name: 2,6-DIMETHYL-4-CYANOPYRIDINE
• Synonyms: 2,6-DIMETHYL-4-CYANOPYRIDINE;4-CYANO-2,6-LUTIDINE;2,6-Dimethylisonicotinonitrile;2,6-Dimethyl-4-pyridinecarbonitrile;4-Cyano-2,6-dimethylpyridine;2,6-dimethylisonicotinonitrile(SALTDATA: FREE);2,6-Dimethylpyridine-4-carbonitrile;2-cyano-2,6-diMethyl-1,2-dihydropyridine-4-carboxylic acid
• CAS NO: 39965-81-6
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• Product Categories: Pyridines;Building Blocks;Pyridine
• Mol File: 39965-81-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 80-82℃
• Boiling Point: 229℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.05
• Vapor Pressure: 0.07mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: 2,6-DIMETHYL-4-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYL-4-CYANOPYRIDINE(39965-81-6)
• EPA Substance Registry System: 2,6-DIMETHYL-4-CYANOPYRIDINE(39965-81-6)

Safety Data

• Statements: 36
• Safety Statements: 26
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 39965-81-6(Hazardous Substances Data)

Usage

Description

2,6-DIMETHYL-4-CYANOPYRIDINE is an organic compound characterized by its pyridine ring structure, featuring two methyl groups at the 2nd and 6th positions and a cyano group at the 4th position. 2,6-DIMETHYL-4-CYANOPYRIDINE is known for its potential applications in various chemical and pharmaceutical processes due to its unique molecular structure and properties.

Uses

Used in Pharmaceutical Industry:
2,6-DIMETHYL-4-CYANOPYRIDINE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to serve as a building block for the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the chemical industry, 2,6-DIMETHYL-4-CYANOPYRIDINE is used as a key intermediate in the synthesis of a wide range of organic compounds. Its reactivity and functional groups make it a valuable component in the creation of various chemical products.
Specific Application:
2,6-DIMETHYL-4-CYANOPYRIDINE is used in the synthetic preparation of 2-ethylthioisonicotinamide, which is an important compound in the development of pharmaceuticals and other chemical products. 2,6-DIMETHYL-4-CYANOPYRIDINE's unique structure and properties make it a crucial component in this specific synthesis process.

InChI:InChI=1/C8H8N2/c1-6-3-8(5-9)4-7(2)10-6/h3-4H,1-2H3

Upstream product

• 1073-23-0 2,6-lutidine N-oxide 
• 151-50-8 potassium cyanide 
• 3512-80-9 4-amino-2,6-lutidine 
• 7732-18-5 water 
• 87117-15-5 1-methoxy-2,6-dimethylpyridinium methyl sulfate 
• 112950-66-0 1,2,6-trimethylpyridinium methosulfate 
• 113708-04-6 2,6-dimethylpyridine-4-carboxamide 
• 557-21-1 zinc(II) cyanide 
• 325142-95-8 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 99-11-6 citrazinic acid 
• 99055-12-6 2,6-dichloro-isonicotinic acid isopropyl ester 
• 1186513-01-8 2,6-dimethyl-isonicotinic acid isopropyl ester 
• 5093-70-9 4-bromo-2,6-dimethylpyridine 

Downstream Products

• 59576-38-4 (2,6-dimethylpyridin-4-yl)(phenyl)methanone 
• 99055-31-9 2,6-dimethyl-1-oxy-isonicotinonitrile 
• 100377-29-5 2,6-dimethyl-1-oxy-isonicotinic acid amide 
• 54221-93-1 2,6-dimethylisonicotinic acid 
• 611233-77-3 2,6-bis(bromomethyl)-4-cyanopyridine 
• 98491-79-3 2,6-dimethyl-1-oxy-isonicotinic acid 
• 99076-00-3 2,6-dimethyl-1-oxy-isonicotinic acid ethyl ester 
• 116600-66-9 (2,6-dimethyl-1-oxy-[4]pyridyl)-phenyl ketone 
• 113708-04-6 2,6-dimethylpyridine-4-carboxamide 
• 72693-15-3 1-(2,6-dimethylpyridin-4-yl)ethan-1-one 
• 1070791-22-8 t-butyl (2,6-dimethylpyridin-4-yl)methylcarbamate 
• 1122091-54-6 N-hydroxy-2,6-dimethyl-isonicotinamidine 
• 1122086-51-4 2-ethyl-4-[3-(2,6-dimethyl-4-pyridinyl)-[1,2,4]oxadiazol-5-yl]-6-methyl-pyridine 
• 1122088-92-9 C₁₉H₂₂N₄S 

Relevant articles and documents

Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups

The number of substituted pyridine pyridinophanes found in the literature is limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis. Most notably, the electrophilic character at the 4-position of pyridine in pyridinophanes presents a unique challenge for introducing electrophilic chemical groups. Likewise, of the few reported, most substituted pyridine pyridinophanes in the literature are limited to electron-donating functionalities. Herein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN, Cl, NO2, and CF3 are introduced. Potentiometric titrations were used to determine the protonation constants of the new pyridinophanes. Further, the influence of such modifications on the chemical behavior is predicted by comparing the potentiometric results to previously reported systems. X-ray diffraction analysis of the 4-Cl substituted species and its Cu(II) complex are also described to demonstrate the metal binding nature of these ligands. DFT analysis is used to support the experimental findings through energy calculations and ESP maps. These new molecules serve as a foundation to access a range of new pyridinophane small molecules and applications in future work.

CGRP RECEPTOR ANTAGONISTS

The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES

The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.