39996-41-3Relevant articles and documents
Heteroaryl imidazolone derivatives as jak inhibitors
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Page/Page column 105-106, (2012/01/06)
New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).
Structure-kinetics relations holding in the amination of six-membered nitrogen-containing heterocyclic compounds
Borodkin,Vorob'ev,Shubin
experimental part, p. 897 - 903 (2011/10/04)
Relative rates of the amination of 3-X- and 4-X-substituted pyridines (X = H, 3-Me, 4-Me, 3-F3C, 3-CN, 4-CN, 3-Cl, 3-Br, 4-MeO, 4-Me 2N), pyrazine, quinoline, isoquinoline, 2,2′- and 4,4′-bipyridines, and 1,10-phenanthroline with O-
Synthesis of N-benzoylamino-1,2,3,6-tetrahydropyridine derivatives as potential anti-inflammatory agents
Mochona, Bereket,Redda, Kinfe K.
, p. 1383 - 1387 (2008/09/18)
(Chemical Equation Presented) N-Benzoylamino-1,2,3,6-tetrahydropyridines 9a-q were synthesized from 4-substituted pyridines in four steps. Amination of pyridines was carried out to prepare intermediate N-aminopyridinium mesylates using mesytelenesulfonyl hydroxmate (MSH) as aminating agent. N-aminopyridinium mestylates reacted with appropriately substituted acyl chlorides to form N-ylides as stable crystalline solids. Partial reduction of N-ylides with mild reducing agent afforded N-benzoylamino-1,2,3,6-tetrahydropyridines in fair to good yields.