400-28-2Relevant articles and documents
Construction of CF3-containing quaternary chiral centers via Michael addition reactions
Agou, Tomohiro,Kawasaki-Takasuka, Tomoko,Kubota, Toshio,Taketsugi, Masahito,Yamazaki, Takashi
, p. 1815 - 1822 (2021/08/13)
Michael addition reactions of a variety of Grignard reagents to 4,4,4-trifluorinated α,β-unsaturated carboxylic acid derivatives with 4-substituted oxazolidin-2-ones as a chiral auxiliary were found to occur smoothly in the presence of CuBr·SMe2 and TMSCl
Catalytic asymmetric hydrogenation of α-CF3- or β-CF3-Substituted acrylic acids using Rhodium(I) complexes with a combination of chiral and achiral ligands
Dong, Kaiwu,Li, Yang,Wang, Zheng,Ding, Kuiling
supporting information, p. 14191 - 14195 (2014/01/06)
Only the mixture works! Acrylic acid derivatives with CF3 substituents in α or β position were efficiently hydrogenated in the presence of a RhI complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph3P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99 %) and high enantioselectivity (92->99 %). Copyright