40004-14-6Relevant articles and documents
Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin
Zlatoidsky,Maliar
, p. 669 - 673 (1996)
Sixteen new esters and amides of 4-acyloxybenzoic acids were prepared and screened as chymotrypsin inhibitors. Inhibiting activities on chymotrypsin differed markedly (>100-0.008 μM). Compounds which contained the 4-benzoyloxyacetyl moiety showed considerably higher activity then dacyloxybenzamides. Compounds 1c and 11f are also weak trypsin inhibitors.