40004-69-1

Basic information

• Product Name: 2-methyl-1,3-thiazole-5-carboxylic acid
• Synonyms: 5-Thiazolecarboxylicacid, 2-Methyl-;2-methyl-1,3-thiazole-5-carboxylic acid;2-Methyl-5-thiazolecarboxylic acid;RU-21933;2-methylthiazole-5-carboxylic acid;2-methyl-1,3-thiazole-5-carboxylic acid(SALTDATA: FREE);5-Carboxy-2-methyl-1,3-thiazole
• CAS NO: 40004-69-1
• Molecular Formula: C₅H₅NO₂S
• Molecular Weight: 143.17
• Product Categories: Thiazole series;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 40004-69-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 0.000473mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-methyl-1,3-thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1,3-thiazole-5-carboxylic acid(40004-69-1)
• EPA Substance Registry System: 2-methyl-1,3-thiazole-5-carboxylic acid(40004-69-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/39
• Safety Statements: 26-37
• RTECS: XJ3678500
• Hazardous Substances Data: 40004-69-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-1,3-thiazole-5-carboxylic acid is a chemical compound with the molecular formula C6H7NO2S. It is a derivative of thiazole, a heterocyclic compound containing both sulfur and nitrogen atoms in its five-membered ring structure. 2-methyl-1,3-thiazole-5-carboxylic acid is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has been reported to exhibit various biological activities, including antibacterial and antifungal properties. Additionally, 2-methyl-1,3-thiazole-5-carboxylic acid has potential applications in the field of materials science, particularly in the development of functional coatings and polymers.

InChI:InChI=1/C5H5NO2S/c1-3-6-2-4(9-3)5(7)8/h2H,1H3,(H,7,8)

Upstream product

• 79836-78-5 ethyl 2-methylthiazole-5-carboxylate 
• 3581-87-1 2-methylthiazole 
• 124-38-9 carbon dioxide 
• 56012-38-5 5-(hydroxymethyl)-2-methylthiazole 

Downstream Products

• 91137-85-8 2-methyl-thiazole-5-carboxylic acid anilide 
• 95074-54-7 2-methyl-thiazole-5-carbothioic acid anilide 
• 60971-72-4 2-methylthiazole-5-carboxylic acid chloride 
• 1148157-33-8 benzyl (2S)-3-methoxy-2-[(2S)-3-methoxy-2-[(2-methyl-1,3-thiazol-5-yl)formamido]propanamido]propanoate 
• 935888-69-0 N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide 
• 1254969-89-5 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid 
• 1254968-50-7 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide 

Relevant articles and documents

Visualizing Compartmentalized Cellular Mg2+ on Demand with Small-Molecule Fluorescent Sensors

The study of intracellular metal ion compartmentalization and trafficking involved in cellular processes demands sensors with controllable localization for the measurement of organelle-specific levels of cations with subcellular resolution. We introduce herein a new two-step strategy for in situ anchoring and activation of a fluorescent Mg2+ sensor within an organelle of choice, using a fast fluorogenic reaction between a tetrazine-functionalized pro-sensor, Mag-S-Tz, and a strained bicyclononyne conjugated to a genetically encoded HaloTag fusion protein of known cellular localization. Protein conjugation does not affect the metal-binding properties of the o-aminophenol-N,N,O-triacetic acid (APTRA)-based fluorescent indicator, which displays a dissociation constant Kd = 3.1 mM suitable for the detection of low millimolar concentrations of chelatable Mg2+ typical of the intracellular environment. We demonstrate the application of our sensing system for the ratiometric detection of Mg2+ in target organelles in HEK 293T cells, providing the first direct comparison of subcellular pools of the metal without interfering signal from other compartments. Activation of the fluorescence in situ through a fluorogenic conjugation step effectively constrains the fluorescence signal to the locale of interest, thus improving the spatial resolution in imaging applications and eliminating the need for washout of mislocalized sensor. The labeling strategy is fully compatible with live cell imaging, and provides a valuable tool for tracking changes in metal distribution that to date have been an unsolved mystery in magnesium biology.

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

GASTRO-RETENTIVE MODIFIED RELEASE DOSAGE FORMS FOR OPROZOMIB AND PROCESS TO MAKE THEREOF

This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.