40034-42-2 Usage
Description
Rosoxacin is a quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid, substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. It is an antibacterial drug with activity against Neisseria gonorrhoeae and has been used for treating urinary tract infections and certain sexually transmitted diseases.
Uses
Used in Pharmaceutical Industry:
Rosoxacin is used as an antibacterial agent for treating urinary tract infections and certain sexually transmitted diseases, such as gonorrhea. It works by inhibiting bacterial DNA replication and protein synthesis, leading to the eradication of the infection.
Brand Name:
Roxadyl (Sterling Winthrop) is a brand name under which rosoxacin is marketed.
Pharmacokinetics
A single oral dose of 300 mg produces a mean peak plasma concentration of 4–5 mg/L at about 2–4 h, with an apparent elimination half-life of about 6 h. Elimination in the urine is partly as the N-oxide metabolite and the glucuronide of this metabolite.Side effects are those common to quinolones, notably gastrointestinal tract and CNS disturbances. About 50% of patients treated with single oral doses of 100–400 mg developed dizziness, drowsiness, altered visual perception and other CNS effects.It is effective as single-dose treatment of patients with urethral and anorectal gonorrhea, but coexistent C. trachomatis infection is not eliminated from most patients and postgonococcal urethritis develops in up to 30%.
Check Digit Verification of cas no
The CAS Registry Mumber 40034-42-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,0,3 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 40034-42:
(7*4)+(6*0)+(5*0)+(4*3)+(3*4)+(2*4)+(1*2)=62
62 % 10 = 2
So 40034-42-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
40034-42-2Relevant articles and documents
Process for preparing antibacterial compounds
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, (2008/06/13)
4-(4-Halo-3-nitrophenyl)pyridines, useful as intermediates in the synthesis of antibacterial 1-alkyl-1,4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids, are obtained by nitrating 4-(4-halophenyl)pyridines. The 4-(4-halo-3-nitrohenyl)pyridines may be converted to the antibacterial agents by reducing them to 4-(3-aminophenyl)pyridines and then subjecting the amino compounds to suitable known reactions.
Alkyl α-[3-(pyridyl)-anilinomethylene]acetoacetates
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, (2008/06/13)
Process of reacting 3-PY-aniline (I) with lower-alkyl acetoacetate (II) and tri-(lower-alkyl) orthoformate (III) to produce lower-alkyl α-(3-PY-anilinomethylene)acetoacetate (IV), heating lower-alkyl α-(3-PY-anilinomethylene)acetoacetate (IV), to produce 3-acetyl-1,4-dihydro-4-oxo-7-PY-quinoline (V) which is tautomeric with 3-acetyl-4-hydroxy-7-PY-quinoline (VA), reacting V (or VA) with a lower-alkylating agent to produce 3-acetyl-1-(lower-alkyl)-1,4-dihydro-4-oxo-7-PY-quinoline (VI) and converting VI to 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-PY-3-quinolinecarboxylic acid (VII), where PY is 4(or 3)-pyridyl or 4(or 3)-pyridyl having one or two lower-alkyl substituents. The compounds of formula VII are known antibacterial agents.
