4004-96-0

Basic information

• Product Name: 4-phenyl-1-(p-tolylsulphonyl)piperazine
• Synonyms: 4-phenyl-1-(p-tolylsulphonyl)piperazine;Piperazine, 1-(4-methylphenyl)sulfonyl-4-phenyl-;1-(p-Tolylsulfonyl)-4-phenylpiperazine;1-Phenyl-4-tosylpiperazine;1-Tosyl-4-phenylpiperazine;Einecs 223-655-6
• CAS NO: 4004-96-0
• Molecular Formula: C₁₇H₂₀N₂O₂S
• Molecular Weight: 316.4179
• EINECS: 223-655-6
• Mol File: 4004-96-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 482.9°Cat760mmHg
• Flash Point: 245.9°C
• Appearance: /
• Density: 1.234g/cm³
• Vapor Pressure: 1.75E-09mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 4-phenyl-1-(p-tolylsulphonyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-1-(p-tolylsulphonyl)piperazine(4004-96-0)
• EPA Substance Registry System: 4-phenyl-1-(p-tolylsulphonyl)piperazine(4004-96-0)

Safety Data

• Hazardous Substances Data: 4004-96-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H20N2O2S/c1-15-7-9-17(10-8-15)22(20,21)19-13-11-18(12-14-19)16-5-3-2-4-6-16/h2-10H,11-14H2,1H3

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 
• 62-53-3 aniline 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 92-54-6 4-phenyl-1-piperazine 

Relevant articles and documents

PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.

Ultrasound-promoted green approach for the synthesis of sulfonamides using natural, stable and reusable Natrolite nanozeolite catalyst at room temperature

Natural Natrolite nanozeolite has been investigated as an efficient and reusable catalyst for the N-sulfonylation of amines under ultrasound irradiation at room temperature. Compared with traditional methods, the significant advantages for method are green solvent, milder and cleaner conditions, higher purity and yields, shorter reaction time, easier work-up procedure and the lower generation of waste or pollutions. The catalyst can be recovered and reused several times without significant loss of its catalytic activity.

One-Pot synthesis of sulfonamides from primary and secondary amine derived sulfonate salts using cyanuric chloride

A convenient, mild and efficient one-pot synthesis of new sulfonamides is described. The reaction of primary or secondary amine derived sulfonate salts in the presence of cyanuric chloride, triethylamine as base, and anhydrous acetonitrile as solvent at room temperature gives the corresponding sulfonamides in good to excellent yields. Georg Thieme Verlag Stuttgart.