40047-23-2

Basic information

• Product Name: 6-Hydroxyindole-2-carboxylic acid
• Synonyms: 6-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID;6-HYDROXYINDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylicacid, 6-hydroxy-
• CAS NO: 40047-23-2
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 40047-23-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 511.361°C at 760 mmHg
• Flash Point: 263.062°C
• Appearance: /
• Density: 1.57g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.78
• Storage Temp.: 2-8°C
• Solubility: DMSO, Methanol (Slightly)
• PKA: 4.58±0.30(Predicted)
• CAS DataBase Reference: 6-Hydroxyindole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxyindole-2-carboxylic acid(40047-23-2)
• EPA Substance Registry System: 6-Hydroxyindole-2-carboxylic acid(40047-23-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 40047-23-2(Hazardous Substances Data)

Usage

General Description

6-Hydroxyindole-2-carboxylic acid is a chemical compound and an intermediate in the biosynthesis of tryptophan. It is also a precursor in the synthesis of a variety of indole-containing natural products. 6-Hydroxyindole-2-carboxylic acid has been studied for its potential applications in drug development, specifically in the field of cancer research and treatment. Its structure and properties make it a useful building block for the synthesis of novel pharmaceutical compounds. Additionally, 6-Hydroxyindole-2-carboxylic acid has shown promise as a potential antioxidant and anti-inflammatory agent, with potential applications in the development of therapeutic drugs for various ailments.

InChI:InChI=1/C9H7NO3/c11-6-2-1-5-3-8(9(12)13)10-7(5)4-6/h1-4,10-11H,(H,12,13)

Upstream product

• 40047-22-1 6-(benzyloxy)-1H-indole-2-carboxylic acid 
• 98081-83-5 methyl 6-methoxy-1H-indole-2-carboxylate 
• 24239-67-6 4-(benzyloxy)-1-methyl-2-nitrobenzene 
• 40047-21-0 (4-benzyloxy-2-nitro-phenyl)-pyruvic acid 
• 16732-73-3 6-Methoxyindole-2-carboxylic acid 

Downstream Products

• 420135-92-8 RG 13579 
• 116350-38-0 6-hydroxy-1H-indole-2-carboxylic acid methyl ester 
• 1093631-72-1 1-(1,1-dimethylethyl) 2-methyl 6-(4-hydroxyphenyl)-1H-indole-1,2-dicarboxylate 
• 1093631-46-9 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1H-indole-2-carboxylic acid 
• 1093256-05-3 3-bromo-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-6-[(2-hydroxyethyl)oxy]-1H-indole-2-carboxamide 
• 1427753-33-0 benzyl 6-hydroxy-1H-indole-2-carboxylate 

Relevant articles and documents

ANTIBODY-DRUG CONJUGATES COMPRISING ANTI-B7-H3 ANTIBODIES

The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications

Demethylation of aromatic methyl ethers using ionic liquids under microwave irradiation

An efficient demethylation reaction for aromatic methyl ethers has been developed. Deprotection reactions give high yields with butylpyridinium bromide under microwave irradiation. Basic and acidic functional groups are tolerated if the reaction is performed under acidic conditions.

Substituted Indoles, Compositions Containing Them, Method for the Production Thereof and Their Use

Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as antican