40070-40-4

Basic information

• Product Name: TriMethyl BroMoorthoacetate
• Synonyms: TriMethyl BroMoorthoacetate;2-bromo-1,1,1-trimethoxyethane
• CAS NO: 40070-40-4
• Molecular Formula: C₅H₁₁BrO₃
• Molecular Weight: 199.04304
• Mol File: 40070-40-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 185.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.388±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility: Benzene (Slightly), Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: TriMethyl BroMoorthoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: TriMethyl BroMoorthoacetate(40070-40-4)
• EPA Substance Registry System: TriMethyl BroMoorthoacetate(40070-40-4)

Safety Data

• Hazardous Substances Data: 40070-40-4(Hazardous Substances Data)

Usage

Description

TriMethyl BroMoorthoacetate, also known as Trimethyl Bromoorthoacetate, is an organic compound that serves as a crucial intermediate in the synthesis of various chemical compounds. It is characterized by its unique chemical structure, which allows it to participate in multiple chemical reactions and contribute to the formation of different products.

Uses

Used in Pharmaceutical Industry:
TriMethyl BroMoorthoacetate is used as an intermediate in the synthesis of 3,6-Bis(2-hydroxyethyl)-2-pyrazinepropanoic Acid (B444100), which is an impurity of Clavulanic Acid (C563750). Clavulanic Acid is a β-lactamase inhibitor, commonly used in combination with other antibiotics to enhance their effectiveness against bacteria that produce β-lactamase enzymes. By being a part of the synthesis process, TriMethyl BroMoorthoacetate plays a significant role in the development and production of this important class of antibiotics.

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 358-98-5 1,2-dibromo-1-fluoro-ethene 
• 124-41-4 sodium methylate 
• 110-86-1 pyridine 
• 7726-95-6 bromine 

Downstream Products

• 79619-12-8 4-(2,3-Dimethoxyphenyl)-1,3-dimethyl-2-piperidinone 
• 922-69-0 1,1-dimethoxyethylene 

Relevant articles and documents

A short and effective synthesis of dimethyl 2-methoxycarbonyl-3-methylenesuccinate

Cycloaddition of ketene dimethyl acetal (7) to dimethyl butynedioate (8) followed by electrocyclic ring opening yields diene 10. This can be hydrolyzed readily to the title compound 1.

An Intramolecular Element Effect in Nucleophilic Vimylic Substitution Reactions

Fluorochloro- and fluorobromoethenes CHX=CFX (X = Cl, Br) in reactions with sodium alkoxides RONa (R = Me, Et, i-Pr, t-Bu) in the corresponding alcohols afford the products of monosubstitution of both chlorine (bromine) and fluorine, as well as orthoesters XCH2C(OR)3 and esters XCH2COOR. The stereochemistry of the reactions and the intramolecular element effect are discussed.