400727-63-1

Basic information

• Product Name: N-Boc-5-aminoisoindoline
• Synonyms: N-Boc-5-aminoisoindoline;N-Boc-5-nitroisoindoline;tert-butyl 5-nitroisoindoline-2-carboxylate;5-Nitro-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester;5-Nitro-2-(tert-butoxycarbonyl)isoindoline;tert-butyl 5-nitro-2,3-dihydro-1H-isoindole-2-carboxylate;2H-Isoindole-2-carboxylic acid, 1,3-dihydro-5-nitro-, 1,1-dimethylethyl ester
• CAS NO: 400727-63-1
• Molecular Formula: C₁₃H₁₆N₂O₄
• Molecular Weight: 234.29422
• Mol File: 400727-63-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 159-162℃
• Boiling Point: 381.655 °C at 760 mmHg
• Flash Point: 184.618 °C
• Appearance: /
• Density: 1.266
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• PKA: -1.83±0.20(Predicted)
• CAS DataBase Reference: N-Boc-5-aminoisoindoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-5-aminoisoindoline(400727-63-1)
• EPA Substance Registry System: N-Boc-5-aminoisoindoline(400727-63-1)

Safety Data

• Hazardous Substances Data: 400727-63-1(Hazardous Substances Data)

Usage

General Description

N-Boc-5-aminoisoindoline is a chemical compound with the molecular formula C14H15NO3. It is a derivative of 5-aminoisoindoline, containing a Boc (tert-butoxycarbonyl) protecting group on the amino group. N-Boc-5-aminoisoindoline has potential applications in organic synthesis, particularly in the field of medicinal chemistry and drug development. Its unique structure and chemical properties make it a valuable building block for the synthesis of diverse organic molecules. N-Boc-5-aminoisoindoline has the potential to be utilized in the development of pharmaceuticals and other bioactive compounds due to its structural features. Additionally, it can serve as a valuable intermediate in the synthesis of various complex organic molecules.

InChI:InChI=1/C13H16N2O4/c1-13(2,3)19-12(16)14-7-9-4-5-11(15(17)18)6-10(9)8-14/h4-6H,7-8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 46053-72-9 5-nitroisoindoline 
• 496-12-8 isoindoline 
• 832-51-9 1-(1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroethanone 
• 1059172-96-1 2,2,2-trifluoro-1-(5-nitroisoindolin-2-yl)ethan-1-one 

Downstream Products

• 264916-06-5 tert‐butyl 5‐amino‐2,3‐dihydro‐1H‐isoindole‐2‐carboxylate 
• 945488-70-0 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine 
• 945488-73-3 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopropoxyphenyl)-β-alanine 
• 945488-71-1 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-ethoxyphenyl)-β-alanine 
• 945488-77-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine 
• 945488-72-2 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-propoxyphenyl)-β-alanine 
• 945488-75-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isobutyloxyphenyl)-β-alanine 
• 945488-74-4 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-butoxyphenyl)-β-alanine 
• 945488-76-6 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopentyloxyphenyl)-β-alanine 
• 807627-84-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine methyl ester 
• 807627-86-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine 
• 1264924-32-4 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate 
• 1264924-35-7 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol 

Relevant articles and documents

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.