400828-91-3

Basic information

• Product Name: tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate;tert-butyl 4-(2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxylate
• CAS NO: 400828-91-3
• Molecular Formula: C18H26N2O2
• Molecular Weight: 302.41124
• Mol File: 400828-91-3.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate(400828-91-3)
• EPA Substance Registry System: tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate(400828-91-3)

Safety Data

• Hazardous Substances Data: 400828-91-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate is a chemical compound with the molecular formula C18H26N2O2. It is a piperidine derivative that contains an indoline and a tert-butyl ester functional group. tert-butyl 4-(indolin-1-yl)piperidine-1-carboxylate has been studied for its potential pharmacological and biological activities, including its potential as a G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5 is a protein kinase that plays a role in regulating the signaling of various receptors in the body. The compound's structure and properties make it a candidate for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 496-15-1 1-indoline 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 170364-89-3 4-(indol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 118511-81-2 1-(4-piperidinyl)-1H-indole 
• 594827-31-3 1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indole 
• 170364-57-5 enzastaurin 
• 616898-64-7 oxo-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 401565-86-4 tert-butyl 4-(5-bromoindolin-1-yl)piperidine-1-carboxylate 
• 1443247-65-1 4-(indolin-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide 

Relevant articles and documents

Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models

A novel series of C(3)-substituted piperdinylindoles were developed as nociceptin opioid receptor (NOP) partial agonists to explore a pharmacological hypothesis that NOP partial agonists would afford a dual pharmacological action of attenuating Parkinson'

PIPERDINYL NOCICEPTIN RECEPTOR COMPOUNDS

The present invention provides novel piperidinyl-containing nociceptin receptor ligand compounds and pharmaceutical compositions useful in the treatment of neurological diseases and conditions where such ligands mediate the negative effects of the condition. Such neurological diseases and conditions include acute and chronic pain, substance abuse/dependence, alcohol addiction, anxiety, depression, sleep disorders, gastrointestinal disorders, renal disorders, cardiovascular disorders and Parkinson's disease.

MULTIVALENT RAS BINDING COMPOUNDS

Described herein are compounds that modulate Ras signaling, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with altered Ras signaling. Further described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds and methods of using such compounds in the treatment of cell proliferative disorders, including cancer.