40089-14-3

Basic information

• Product Name: 2-o-tolylacetamide
• Synonyms: 2-o-tolylacetamide
• CAS NO: 40089-14-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149
• Mol File: 40089-14-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-o-tolylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-o-tolylacetamide(40089-14-3)
• EPA Substance Registry System: 2-o-tolylacetamide(40089-14-3)

Safety Data

• Hazardous Substances Data: 40089-14-3(Hazardous Substances Data)

Upstream product

• 22364-68-7 2-tolylmethylnitrile 
• 10166-09-3 (o-tolyl)acetyl chloride 
• 644-36-0 o-methylphenylacetic acid 
• 95-47-6 o-xylene 
• 89-92-9 2-methylbenzyl bromide 

Downstream Products

• 51463-24-2 N-formyl-2-(o-methylphenyl)acetamide 
• 1019877-98-5 C₂₁H₁₆N₂O 
• 1443982-60-2 C₂₅H₂₄N₂O₆ 
• 1443982-56-6 C₁₉H₁₄N₂O₂ 
• 1443982-58-8 C₄₉H₄₈N₂O₉ 
• 82082-44-8 N-benzyl-2-(2-methylphenyl)acetamide 

Relevant articles and documents

A CO2-mediated base catalysis approach for the hydration of triple bonds in ionic liquids

Herein, we report a CO2-mediated base catalysis approach for the activation of triple bonds in ionic liquids (ILs) with anions that can chemically capture CO2 (e.g., azolate, phenolate, and acetate), which can achieve hydration of triple bonds to carbonyl chemicals. It is discovered that the anion-complexed CO2 could abstract one proton from proton resources (e.g., IL cation) and transfer it to the CN or CC bonds via a six-membered ring transition state, thus realizing their hydration. In particular, tetrabutylphosphonium 2-hydroxypyridine shows high efficiency for hydration of nitriles and CC bond-containing compounds under a CO2 atmosphere, affording a series of carbonyl compounds in excellent yields. This catalytic protocol is simple, green, and highly efficient and opens a new way to access carbonyl compounds via triple bond hydration under mild and metal-free conditions.

Synthesis of α-Arylcarboxylic acid amides from silyl enol ether via migratory Amidation with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate

α-Arylcarboxylic acid amides were synthesized by reacting silyl enol ethers of aryl ketones and 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP,1). Silyl enol ethers react with ADMP 1 to give N-(α-arylacyl) guanidines via the migration of aryl groups in enol ethers. The products were transformed to the corresponding α-aryl acetamides by treating with LiAlH4.

PHENYLTHIOACETIC ACID DERIVATIVES AND USE THEREOF

The invention relates to novel phenylthioacetic acid derivatives of formula (I), to a method for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidaemia and arteriosclerosis. The compounds act as modulators for the PRAR-alpha receptor.