40098-40-6Relevant articles and documents
Prostaglandins and congeners. 20. Synthesis of prostaglandins via conjugate addition of lithium trans-1-alkenyltrialkylalanate reagents. A novel reagent for conjugate 1,4-additions
Bernady,Floyd,Poletto,Weiss
, p. 1438 - 1446 (2007/10/06)
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11,15-DIHYDROXY-9-OXOPROST-13-YNOIC ACID
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, (2008/06/13)
3-(Optionally oxygenated)-5-oxocyclopent-1-enealkanoic acids and their alkyl esters are allowed to react with appropriate alkenyl copper, alkenyl boron, alkynyl boron, alkynyl gallium or alkynyl aluminum compounds to produce the corresponding 2-(3-hydroxy-3-optionally alkylated!-1-alkenyl)cyclopentanealkanoic acids, 2-(3-hydroxy-3-optionally alkylated!-1-alkynyl)cyclopentanealkanoic acids and their esters. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their central nervous system-affective, anti-bacterial, anti-fungal and prostaglandin antagonist activity.