40104-33-4

Basic information

• Product Name: 5-bromothiophene-2-carbaldehyde thiosemicarbazone
• Synonyms: (2E)-2-[(5-Bromo-2-thienyl)methylene]hydrazinecarbothioamide; hydrazinecarbothioamide, 2-[(5-bromo-2-thienyl)methylene]-, (2E)-
• CAS NO: 40104-33-4
• Molecular Formula: C₆H₆BrN₃S₂
• Molecular Weight: 264.1659
• Mol File: 40104-33-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377°C at 760 mmHg
• Flash Point: 181.8°C
• Density: 1.85g/cm³
• Vapor Pressure: 6.98E-06mmHg at 25°C
• Refractive Index: 1.754
• CAS DataBase Reference: 5-bromothiophene-2-carbaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromothiophene-2-carbaldehyde thiosemicarbazone(40104-33-4)
• EPA Substance Registry System: 5-bromothiophene-2-carbaldehyde thiosemicarbazone(40104-33-4)

Safety Data

• Hazardous Substances Data: 40104-33-4(Hazardous Substances Data)

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 79-19-6 thiosemicarbazide 
• 7311-46-8 2-bromo-5-(chloromethyl)thiophene 
• 98-03-3 thiophene-2-carbaldehyde 

Relevant articles and documents

*SYNTHESIS AND PSYCHOTROPIC PROPERTIES OF AZOMETHINE dERIVATIVES OF tHIOPHENE

A series of azomethine derivatives was obtained by condensation of 2-thiophenaldehyde and 5-substituted (alkyl, bromine, tert-butyl, trimethylsilyl)-2-thiophenaldehydes with semicarbazide, thiosemicarbazide, aminohydantoin and 2-semicarbazide acetic acid.Their psychotropic activity was investigated.It was found that incorporation of a tert-butyl group in position 5 of the thiophene ring potentiates the toxicity of the compound. 5-Trimethylsilyl- and 5-tetr-butyl-2-thiophenaldehyde thiosemicarbazones exhibit elevated neurotropic activity.These compounds cause the stimmulating effect of phenamine to appear, increasing the motor activity of animals by two times and prolonging the effect of hexenal-induced sleep.Substitution of thiosemicarbazone by semicarbazone decreases the activity except for hexenal sleep, where the 5-tert-butyl-2-thiophenaldehyde semicarbazone was 1.5 times more active than the thiosemicarbazone.

Biological evaluation and in silico molecular docking study of a new series of thiazol-2-yl-hydrazone conglomerates

A new series of hybridized thiazol-2-yl-hydrazone derivatives having diverse substituents were designed, synthesized, and screened for their anti-inflammatory property by a carrageenan-induced paw edema method. The compounds 11a, 11b, 11c, 11d, 11e, 11g, 11m and 11p revealed significant inhibition when compared to Diclofenac sodium. Subsequently, two highly potent compounds (11d and 11e) were evaluated for their cytotoxic effect on the tumor cell line. The binding interactions of thiazol-2-yl-hydrazones with the cyclooxygenase-2 (COX-2) protein (PDB: 3LN1) displayed effective interactions with Arg-120, Tyr-385 and Tyr-355 amino acids, the main criteria of the COX-2 inhibitor. In addition, all the compounds showed moderate to good in vitro antibacterial activity. Most active benzyloxy derivatives were also tested to understand the radical scavenging efficacy by the 2,2-diphenyl-1-picrylhydrazyl method. Graphical Abstract: [Figure not available: see fulltext.].