40105-30-4

Basic information

• Product Name: 4-METHYQUINOLINE-2-CARBOXALDEHYDE
• Synonyms: 4-METHYQUINOLINE-2-CARBOXALDEHYDE;4-methylquinoline-2-carbaldehyde
• CAS NO: 40105-30-4
• Molecular Formula: C11H9NO
• Molecular Weight: 171.19526
• Mol File: 40105-30-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 331.4°C at 760 mmHg
• Flash Point: 162.2°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0.000156mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 4.31±0.50(Predicted)
• CAS DataBase Reference: 4-METHYQUINOLINE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYQUINOLINE-2-CARBOXALDEHYDE(40105-30-4)
• EPA Substance Registry System: 4-METHYQUINOLINE-2-CARBOXALDEHYDE(40105-30-4)

Safety Data

• Hazardous Substances Data: 40105-30-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 536, 1986 DOI: 10.1021/jo00354a026

InChI:InChI=1/C11H9NO/c1-8-6-9(7-13)12-11-5-3-2-4-10(8)11/h2-7H,1H3

Upstream product

• 1198-37-4 2,4-dimethylquinoline 
• 110-88-3 1,3,5-Trioxan 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 67-56-1 methanol 
• 33787-85-8 (4-methyl-quinolin-2-yl)-methanol 
• 99687-44-2 2-(dioxolan-2-yl)-4-methylquinoline 
• 40105-26-8 4-methyl-2-(1,3,5-trioxan-2-yl)quinoline 
• 7446-08-4 selenium(IV) oxide 
• 108-38-3 m-xylene 
• 64658-04-4 2-bromo-4-methyl-quinoline 
• 201230-82-2 carbon monoxide 
• 68-12-2 N,N-dimethyl-formamide 
• 607-66-9 4-methylquinolin-2-ol 
• 20461-86-3 2,2-diethoxy acetic acid 

Relevant articles and documents

Redox-triggered interconversion between piperidine chair conformations in a Cu(I/II) complex

A redox-induced six-membered ring chair-chair conformational interconversion in a copper-coordinated trans-piperidine tripodal ligand is demonstrated. Each group of the 1,2,3-substituted ring can potentially ligate the metal; two equatorial groups ligate the metal in the CuI state leaving a disassociated, axial group. However, all three groups (two axial and one equatorial) ligate the metal in the CuII state. Exciton-coupled circular dichroism (ECCD) and 2D NMR were used to characterize the structures.

Iron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines

The aldehyde group is one of the most versatile intermediates in synthetic chemistry, and the introduction of an aldehyde group into heteroarenes is important for the transformation of molecular structure. Herein, we achieved the direct formylation of benzothiazo/les and isoquinolines. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using commercially available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction can be performed under exceedingly mild reaction conditions and exhibits broad functional group tolerance.

Surgical Cleavage of Unstrained C(sp3)?C(sp3) Bonds in General Alcohols for Heteroaryl C?H Alkylation and Acylation

We reported herein a predictable and surgical cleavage of carbon-carbon bond in alcohols. A wide range of 1°, 2° and 3° alcohols including sugars and steroids without ring strain or steric hindrance were all compatible with this system. Also it offered a green and practical strategy for generation of alkyl/acyl radicals using alcohols as the sources. Besides, the features of visible-light-initiation, catalyst and metal free, excellent selectivity and mild conditions make it valuable and attractive. (Figure presented.).