40110-96-1Relevant articles and documents
B-Ring-modified and/or 5-demethylated nobiletin congeners: Inhibitory activity against pro-MMP-9 production
Oshitari, Tetsuta,Okuyama, Yuji,Miyata, Yoshiki,Kosano, Hiroshi,Takahashi, Hideyo,Natsugari, Hideaki
, p. 7085 - 7092 (2012/01/02)
Three metabolites and 12 analogues of nobiletin (1) were synthesized. Whereas nobiletin derivatives 2-4 inhibited pro-MMP-9 production similarly in both PMA- and TNF-α-stimulated human lens epithelial cells, the 2′-hydroxylated analogue 5a exerted marked inhibitory effects (IC 50: 0.4 μM) on PMA-treated cells, which were 170-fold more potent than those on TNF-α-treated cells. This activity may be closely related to PKC-mediated transcriptional regulation of pro-MMP-9.
Inhibitor of aldose reductase
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, (2008/06/13)
An inhibitor of aldose reductase which contains, as the effective ingredient, a flavone derivative having the following formula: STR1 wherein R1 is hydrogen atom or hydroxyl group, R2 is hydroxyl group or methoxyl group or a pharmace
Synthesis and antiviral activity of 4'-hydroxy-5,6,7,8-tetramethoxyflavone.
Burnham,Sidwell,Tolman,Stout
, p. 1075 - 1076 (2007/10/10)
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