40116-79-8

Basic information

• Product Name: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol
• Synonyms: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol
• CAS NO: 40116-79-8
• Molecular Weight: 179.262
• Mol File: 40116-79-8.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol(40116-79-8)
• EPA Substance Registry System: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol(40116-79-8)

Safety Data

• Hazardous Substances Data: 40116-79-8(Hazardous Substances Data)

Upstream product

• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 
• 123-62-6 propionic acid anhydride 
• 3506-36-3 3-dimethylaminopropiophenone 
• 1270016-44-8 (R)-N,N-dimethylamino-1-phenylpropanol oxalate 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 

Downstream Products

• 1270016-46-0 (R)-N,N-dimethyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane 
• 162938-15-0 (R)-N-methyl-3-(2-methylthiophenoxy)-3-phenyl-propylamine 
• 56225-81-1 N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine 
• 222961-69-5 [(R)-3-(2-Methanesulfinyl-phenoxy)-3-phenyl-propyl]-dimethyl-amine 
• 114247-09-5 (R)-fluoxetine hydrochloride 

Relevant articles and documents

Amino alcohols using the optically active amino alcohol derivative bi- Nord complex boron - -

Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

A method for preparing optically active 3-amino-1-phenylpropanol derivatives as an intermediate and a method for preparing optically active pharmaceutical products using the same

The present invention relates to a method for preparing a 3-amino-1-phenylpropanol derivative having (R) or (S) optical activity with 80% or more of an enantiomeric excess (ee), which includes a step of performing an asymmetric reduction reaction in the presence of a spiroborate ester catalyst and a hydrogen donor. The invention also relates to a method for preparing an optically active pharmaceutical product, which includes a step of preparing a (R)- or (S)-3-amino-1-phenylpropanol derivative, that is an intermediate, by using the catalyst.(AA) 3-amino-1-phenylpropanol(BB) Tomoxetine(CC) Nisoxetine(DD) FluoxetineCOPYRIGHT KIPO 2016

NOVEL PROCESS FOR THE PREPARATION OF 4-HYDROXY ATOMOXETINE

The present invention relates to novel process for the preparation of 4-hydroxy Atomoxetine or its pharmaceutically acceptable salts thereof. The present invention also relates to novel intermediates used in the preparation of 4-hydroxy Atomoxetine.