40118-09-0

Basic information

• Product Name: 1H-Indole-3-ethanol, 2,3-dihydro-
• Synonyms: 2-Indolin-3-yl-aethanol;2-(2,3-dihydro-indol-3-yl)-ethanol;2-indolin-3-yl-ethanol;1H-Indole-3-ethanol,2,3-dihydro;(indolin-3-yl)ethanole;3-(2-ethanol)-indoline
• CAS NO: 40118-09-0
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Mol File: 40118-09-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-ethanol, 2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-ethanol, 2,3-dihydro-(40118-09-0)
• EPA Substance Registry System: 1H-Indole-3-ethanol, 2,3-dihydro-(40118-09-0)

Safety Data

• Hazardous Substances Data: 40118-09-0(Hazardous Substances Data)

Upstream product

• 526-55-6 2-(3-indole)-ethanol 
• 85676-99-9 (2,3-dihydroindol-3-yl)acetic acid methyl ester 
• 87-51-4 indole-3-acetic acid 

Downstream Products

• 526-55-6 2-(3-indole)-ethanol 

Relevant articles and documents

Aerobic Dehydrogenation of N-Heterocycles with Grubbs Catalyst: Its Application to Assisted-Tandem Catalysis to Construct N-Containing Fused Heteroarenes

An aerobic dehydrogenation of nitrogen-containing heterocycles catalyzed by Grubbs catalyst is developed. The reaction is applicable to various nitrogen-containing heterocycles. The exceptionally high functional group compatibility of this method was confirmed by the oxidation of an unprotected dihydroindolactam V to indolactam V. Furthermore, by taking advantage of the oxygen-mediated structural change of the Grubbs catalyst, we integrated ring-closing metathesis and subsequent aerobic dehydrogenation to develop the novel assisted-tandem catalysis using molecular oxygen as a chemical trigger. The utility of the assisted-tandem catalysis was demonstrated by the concise synthesis of N-containing fused heteroarenes including a natural antibiotic, pyocyanine.

Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers

A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 μM which was much better than (+)-Madindoline A (IC50 = 21 μM), a known inhibitor of IL-6.

NOVEL 2,3-DIHYDROINDOLE COMPOUNDS

The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT 2A receptor is implicated.