401567-76-8

Basic information

• Product Name: 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE
• Synonyms: 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE
• CAS NO: 401567-76-8
• Molecular Formula: C15H13F6N3
• Molecular Weight: 349.27
• Mol File: 401567-76-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 405.7°Cat760mmHg
• Flash Point: 199.2°C
• Appearance: /
• Density: 1.385g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE(401567-76-8)
• EPA Substance Registry System: 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE(401567-76-8)

Safety Data

• Hazardous Substances Data: 401567-76-8(Hazardous Substances Data)

Usage

General Description

2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE is a chemical compound with a molecular formula C19H18F6N4. It is a quinoline derivative that contains two trifluoromethyl groups and a piperazine moiety. 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE has potential pharmaceutical applications, particularly in the field of drug discovery and development. Its unique structure and functional groups make it an interesting molecule for further research and exploration in the search for new therapeutic agents. Additionally, the presence of the piperazine moiety suggests potential use in the development of drugs targeting central nervous system disorders. However, further investigation and testing are necessary to fully understand the potential uses and properties of 2,8-BIS(TRIFLUOROMETHYL)-4-(PIPERAZIN-1-YL)QUINOLINE.

InChI:InChI=1/C15H13F6N3/c16-14(17,18)10-3-1-2-9-11(24-6-4-22-5-7-24)8-12(15(19,20)21)23-13(9)10/h1-3,8,22H,4-7H2

Upstream product

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Relevant articles and documents

New hybrid trifluoromethylquinolines as antiplasmodium agents

Malaria remains a major public health problem worldwide, and it is responsible for high rates of morbidity and mortality. Resistance to current antimalarial drugs has been identified, and new drugs are urgently needed. In this study, we designed and synthesized seventeen novel quinolines based on the structures of mefloquine ((2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol) and amodiaquine (4-((7-chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol) using ring bioisosteric replacement and molecular hybridization of the functional groups. The compounds were evaluated in vitro against Plasmodium falciparum and in vivo in mice infected with P. berghei. All derivatives presented anti-P. falciparum activity with IC50 values ranging from 0.083 to 33.0 μM. The compound with the best anti-P. falciparum activity was N-(5-methyl-4H-1,2,4-triazol-3-yl)-2,8-bis(trifluoromethyl)quinolin-4-amine (12) which showed an IC50 of 0.083 μM. The three most active compounds were selected for antimalarial activity tests against P. berghei-infected mice. Compound 12 was the most active on the 5th day after infection, reducing parasitemia by 66%, which is consistent with its in vitro activity. This is an important result as 12, a simpler molecule than mefloquine, does not contain the stereogenic center, and consequently, its synthesis in the laboratory is easier and less expensive. This system proved promising for the design of potential antimalarial compounds.