401942-22-1Relevant articles and documents
SYNTHESIS AND PROPERTIES OF PEPTIDE FRAGMENTS OF THE S-REGION OF THE SURFACE PROTEIN OF THE HEPTATITIS B VIRUS
Kuranova, I. L.,Churkina, S. I.,Os'mak, A. V.,Filonova, E. B.,Lyudmirova, V. L.,Noskova, O. V.
, p. 355 - 361 (2007/10/02)
A peptide fragment with the 140-146 sequence of the main component of the surface protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution.Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained.The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied.The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.