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40203-89-2

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40203-89-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 40203-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,2,0 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40203-89:
(7*4)+(6*0)+(5*2)+(4*0)+(3*3)+(2*8)+(1*9)=72
72 % 10 = 2
So 40203-89-2 is a valid CAS Registry Number.

40203-89-2Relevant articles and documents

Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin

Damalanka, Vishnu C.,Wildman, Scott A.,Janetka, James W.

, p. 1646 - 1655 (2019)

Matriptase and hepsin are type II transmembrane serine proteases (TTSPs). Along with related S1 trypsin like serine protease HGFA (hepatocyte growth factor activator), their unregulated proteolytic activity has been associated with cancer including tumor progression and metastasis. These three proteases have two substrates in common, hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP), the ligands for MET and recepteur d'origine nantais (RON) receptor tyrosine kinases. Mechanism-based tetrapeptide and benzamidine inhibitors of these proteases have been shown to block HGF/MET and MSP/RON cancer cell signaling. Herein, we have rationally designed a new class of peptidomimetic hybrid small molecule piperidine carbamate dipeptide inhibitors comparable in potency to much larger tetrapeptides. We have identified multiple compounds which have potent activity against matriptase and hepsin and with excellent selectivity over the off-target serine proteases factor Xa and thrombin.

COMPOUNDS AND METHODS FOR TREATING CANCER, VIRAL INFECTIONS, AND ALLERGIC CONDITIONS

-

Paragraph 0276; 0278, (2021/01/23)

The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine proteases (e.g. C

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease

Galasiti Kankanamalage, Anushka C.,Kim, Yunjeong,Rathnayake, Athri D.,Alliston, Kevin R.,Butler, Michelle M.,Cardinale, Steven C.,Bowlin, Terry L.,Groutas, William C.,Chang, Kyeong-Ok

, p. 6239 - 6248 (2017/08/02)

Ester and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve their pharmacokinetic and pharmacodynamic properties. The inhibitory activity of the compounds against norovirus 3C-like protease in enzyme and cell-

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