4023-34-1 Usage
Description
Cyclopropanecarbonyl Chloride, also known as Cyclopropanecarboxylic Acid Chloride, is an organic compound with the chemical formula C4H5ClO2. It is a clear colorless to slightly yellow liquid and is commonly used as an alkylating reagent in the synthesis of various chemical building blocks.
Uses
Used in Pharmaceutical Industry:
Cyclopropanecarbonyl Chloride is used as an alkylating reagent for the preparation of chemical building blocks, which are essential in the development of pharmaceutical compounds. These building blocks include formylcyclopropane, cyclopropanecarboxylic acid hydrazide, bis(cyclopropylcarbonyl) peroxide, 1-cyclopropanecarboxamide, 2-cyclopropylcarbonylcyclohexane-1,3-diones, and cyclopropyl analog of triazolopiperazine-amides. The use of Cyclopropanecarbonyl Chloride in the pharmaceutical industry aids in the synthesis of novel drug candidates with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, Cyclopropanecarbonyl Chloride serves as a versatile alkylating agent, enabling the creation of a wide range of chemical compounds. Its reactivity and functional group compatibility make it a valuable component in the synthesis of various organic molecules, contributing to the advancement of chemical research and development.
Used in Research and Development:
Cyclopropanecarbonyl Chloride is also utilized in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique properties and reactivity allow researchers to investigate new pathways and develop innovative applications in various scientific fields, including materials science, pharmaceuticals, and agrochemicals.
Purification Methods
If the IR shows OH bands, then some hydrolysis to the free acid must have occurred. In this case heat with oxalyl chloride at 50o for 2hours or SOCl2 for 30minutes, then evaporate and distil three times using a Dufton column (p 10). Store it in an inert dry atmosphere, preferably in sealed tubes. Strong IRRITANT. If it is free from OH bands, then just distil it in vacuo and store as before. [Jeffrey & Vogel J Chem Soc 1804 1948, Beilstein 9 IV 4.]
Check Digit Verification of cas no
The CAS Registry Mumber 4023-34-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,2 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4023-34:
(6*4)+(5*0)+(4*2)+(3*3)+(2*3)+(1*4)=51
51 % 10 = 1
So 4023-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H5ClO/c5-4(6)3-1-2-3/h3H,1-2H2
4023-34-1Relevant articles and documents
Synthesis of N-trifluoromethyl amides from carboxylic acids
Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.
supporting information, p. 2245 - 2255 (2021/08/12)
Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.
Isoalantolactone derivative, pharmaceutical composition and application thereof
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Paragraph 0014, (2019/02/02)
The invention relates to an isoalantolactone derivative, a pharmaceutical composition and application thereof, especially use of the isoalantolactone derivative shown as formula (I) or a salt pharmaceutical compound thereof in preparation of adjuvant drugs treating cancer, a pharmaceutical composition containing a therapeutically effective amount of isoalantolactone derivative (I) or its salt anda pharmaceutically acceptable carrier or a composition with other anticancer drugs.
CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS
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Paragraph 0432, (2019/07/13)
The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I); where A1, A2, G, R1, R2, R3, R4, and W are described herein.