402476-91-9Relevant articles and documents
Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B
Larsen, Scott D.,Barf, Tjeerd,Liljebris, Charlotta,May, Paul D.,Ogg, Derek,O'Sullivan, Theresa J.,Palazuk, Barbara J.,Schostarez, Heinrich J.,Stevens, F. Craig,Bleasdale, John E.
, p. 598 - 622 (2007/10/03)
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the β-subunit of the insulin receptor (IR), thereby attenuating receptor tyrosine kinase acti