40248-00-8

Basic information

• Product Name: 5-(DiMethylaMino)-1,3-benzenediol
• Synonyms: 5-(DiMethylaMino)-1,3-benzenediol;5-Dimethylamino-benzene-1,3-diol
• CAS NO: 40248-00-8
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.17844
• Mol File: 40248-00-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.8±10.0 °C(Predicted)
• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• PKA: 9.55±0.10(Predicted)
• CAS DataBase Reference: 5-(DiMethylaMino)-1,3-benzenediol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(DiMethylaMino)-1,3-benzenediol(40248-00-8)
• EPA Substance Registry System: 5-(DiMethylaMino)-1,3-benzenediol(40248-00-8)

Safety Data

• Hazardous Substances Data: 40248-00-8(Hazardous Substances Data)

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 40603-85-8 C₅F₈N₂(CH₃)C₆H₅ 
• 744208-14-8 3-(dimethylamino)-5-[(triisopropylsilyl)oxy]phenol 
• 1253783-59-3 3-hydroxy-N,N,N-trimethyl-5-{4-[(2-oxo-2H-chromen-7-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-60-6 3-hydroxy-N,N,N-trimethyl-5-{4-[(3-methyl-2-oxo-2H-chromen-7-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-61-7 3-hydroxy-N,N,N-trimethyl-5-{4-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-62-8 3-hydroxy-N,N,N-trimethyl-5-(4-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]oxy}butoxy)benzenaminium iodide 
• 1253783-63-9 3-{4-[(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]butoxy}-5-hydroxy-N,N,N-trimethylbenzenaminium iodide 
• 1253783-64-0 3-({5-[(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]pentyl}oxy)-5-hydroxy-N,N,N-trimethylbenzenaminium iodide 
• 1253783-65-1 3-hydroxy-N,N,N-trimethyl-5-{4-[(6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-66-2 N-ethyl-3-hydroxy-N,N-dimethyl-5-{4-[(6-oxo-7,8,9,10-tetrahydro-6H-benzo[c]chromen-3-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-67-3 3-hydroxy-N,N,N-trimethyl-5-{4-[(6-oxo-6H-benzo[c]chromen-3-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-68-4 3-[(3-{[(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl)oxy]methyl}benzyl)oxy]-5-hydroxy-N,N,N-trimethylbenzenaminium iodide 
• 1253783-69-5 3-hydroxy-N,N,N-trimethyl-5-{4-[(2-oxo-2H-chromen-3-yl)oxy]butoxy}benzenaminium iodide 
• 1253783-70-8 3-{4-[(6,7-dimethoxy-2-oxo-2H-chromen-3-yl)oxy]butoxy}-5-hydroxy-N,N,N-trimethylbenzenaminium iodide 

Relevant articles and documents

Partial deoxygenation of glycerol catalyzed by iridium pincer complexes

Iridium pincer complexes (POCOP)Ir(CO) (POCOP = κ3-C 6H3-1,3-[OP(tBu)2]2) and substituted POCOP derivatives catalyze deoxygenation of glycerol to n-propanol and 1,3-propanediol in good yield under moderate conditions (acidic aqueous dioxane, 200 C, 80 bar H2). Catalyst solubility in the polar reaction mixture is improved by incorporation of a polar moiety in the para position of the POCOP phenyl ring, with the best results obtained with a dimethylamino substituent.

Hydrodabcyl: A Superior Hydrophilic Alternative to the Dark Fluorescence Quencher Dabcyl

Dark fluorescence quenchers are nonfluorescent dyes that can modulate the fluorescence signal of an appropriate fluorophore donor in a distance-dependent manner. Dark quenchers are extensively used in many biomolecular analytical applications, such as studies with fluorogenic protease substrates or nucleic acids probes. A very popular dark fluorescence quencher is dabcyl, which is a hydrophobic azobenzene derivative. However, its insolubility in water may constitute a major drawback, especially during the investigation of biochemical systems whose natural solvent is water. We designed and synthesized a new azobenzene-based dark quencher with excellent solubility in aqueous media, which represents a superior alternative to the much-used dabcyl. The advantage of hydrodabcyl over dabcyl is exemplarily demonstrated for the cleavage of the fluorogenic substrate hydrodabcyl-Ser-Phe-EDANS by the proteases thermolysin and papain.

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