4025-77-8

Basic information

• Product Name: CHLOROSULFONYLACETYL CHLORIDE
• Synonyms: CHLOROSULFONYLACETYL CHLORIDE;(chlorosulfonyl)-acetylchlorid;(chlorosulphonyl)acetyl chloride;Acetyl chloride, (chlorosulfonyl)-;(Chlorosulfonyl)acetic acid chloride;Chlorosulfonylacetyl chloride,98%;2-(chlorosulfonyl)acetyl chloride
• CAS NO: 4025-77-8
• Molecular Formula: C₂H₂Cl₂O₃S
• Molecular Weight: 177.01
• EINECS: 223-693-3
• Product Categories: Organics;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 4025-77-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 71-72 °C/1 mmHg(lit.)
• Flash Point: 113 °C
• Appearance: Off-white to brown/Powder, Crystals and/or Chunks
• Density: 1.669
• Vapor Pressure: 1.29E-22mmHg at 25°C
• Refractive Index: n20/D 1.493(lit.)
• Storage Temp.: water-free area
• CAS DataBase Reference: CHLOROSULFONYLACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROSULFONYLACETYL CHLORIDE(4025-77-8)
• EPA Substance Registry System: CHLOROSULFONYLACETYL CHLORIDE(4025-77-8)

Safety Data

• Hazard Codes: C
• Statements: 34-14-36/37
• Safety Statements: 8-45-36/37/39-26-28-27
• RIDADR: 1760
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 4025-77-8(Hazardous Substances Data)

Usage

Description

CHLOROSULFONYLACETYL CHLORIDE is an organic compound with the chemical formula ClCOCH2SO2Cl. It is a colorless to pale yellow liquid that is highly reactive due to the presence of two electrophilic chlorine atoms. CHLOROSULFONYLACETYL CHLORIDE is known for its versatility in chemical reactions and its ability to act as a chlorosulfonating and acylating agent.

Uses

Used in Pharmaceutical Industry:
CHLOROSULFONYLACETYL CHLORIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity allows for the formation of new chemical entities with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, CHLOROSULFONYLACETYL CHLORIDE is utilized as a valuable reagent for the preparation of novel chemical compounds. Its ability to participate in various chemical reactions makes it a useful tool for exploring new chemical pathways and developing innovative materials.
Used in the Preparation of Antagonists:
CHLOROSULFONYLACETYL CHLORIDE is used as a reactant in the preparation of novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor. These antagonists have potential applications in the treatment of various cardiovascular diseases, such as thrombosis and atherosclerosis.
Used in Peptide and Protein Analysis:
CHLOROSULFONYLACETYL CHLORIDE is employed in the N-terminal derivatization of peptides for rapid determination of peptide or protein sequences by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). This technique is widely used in proteomics research to identify and characterize proteins, which is crucial for understanding their functions and roles in various biological processes.

InChI:InChI=1/C30H38N2O7/c1-20(15-21-16-26(38-5)27(39-6)18-25(21)37-4)28(33)32-14-11-30(19-32)9-12-31(13-10-30)29(34)23-17-22(35-2)7-8-24(23)36-3/h7-8,15-18H,9-14,19H2,1-6H3

Upstream product

• 123-43-3 sulfoacetic acid 
• 10025-87-3 trichlorophosphate 
• 10026-13-8 phosphorus pentachloride 
• 7719-09-7 thionyl chloride 
• 64-19-7 acetic acid 

Downstream Products

• 7117-27-3 phenylsulfamoyl-acetic acid anilide 
• 159215-13-1 benzyloxycarbonylmethylsulfonyl chloride 
• 303153-12-0 isopropyl (chlorosulfonyl)acetate 
• 123-43-3 sulfoacetic acid 
• 4025-78-9 chlorosulfonyl-acetic acid 
• 946127-82-8 (3-acetylaminophenylsulfamoyl)acetic acid ethyl ester 
• 1228789-28-3 C₁₀H₁₁ClN₂O₃S₂ 
• 1080475-38-2 N'-methyl-2-(2-methyl-2-(phenylcarbonoselenoyl)hydrazinyl)-2-oxo-N'-(phenylcarbonoselenoyl)ethanesulfonohydrazide 
• 255872-88-9 N-(3-trifluoromethyl-phenyl)-2-(3-trifluoromethyl-phenylsulfamoyl)-acetamide 
• 1009563-46-5 N'-methyl-2-(2-methyl-2-(phenylcarbonothionyl)hydrazinyl)-2-oxo-N'-(phenylcarbonothionyl)ethanesulfonohydrazide 
• 230962-91-1 CT50547 
• 159215-11-9 p-nitrobenzyloxycarbonylmethylsulfonylchloride 
• 75-77-4 chloro-trimethyl-silane