40256-14-2

Basic information

• Product Name: Ethanol, 2-(4-piperidinyloxy)-
• CAS NO: 40256-14-2
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Mol File: 40256-14-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-(4-piperidinyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(4-piperidinyloxy)-(40256-14-2)
• EPA Substance Registry System: Ethanol, 2-(4-piperidinyloxy)-(40256-14-2)

Safety Data

• Hazardous Substances Data: 40256-14-2(Hazardous Substances Data)

Upstream product

• 86450-38-6 2-(pyridin-4-yloxy)ethan-1-ol 
• 108-96-3 4-pyridone 
• 163210-40-0 tert-butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Downstream Products

• 1056877-76-9 C₁₄H₂₁N₃O₄ 
• 40255-57-0 10-<3-<4-(2-Hydroxyaethoxy)-piperidino>-propyl>-2-trifluormethyl-phenothiazin 
• 335349-86-5 {5-[4-(2-hydroxy-ethoxy)-piperidin-1-yl]-4-iodo-2-nitro-phenyl}-carbamic acid tert.-butyl ester 
• 1353983-03-5 2-(1-methyl-piperidin-4-yloxy)-ethanol 
• 288625-98-9 N-(2-bromo-4(1-methylethyl)phenyl)-N-ethyl-4-((4,4-ethylenedioxypiperidino)carbonyl)-6-methylpyrimidinamine 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

INDANOL DERIVATIVE

The present invention provides a compound having the following general formula (I) which is useful as a neurokinin receptor antagonist: (wherein, R1, R2: optionally substituted (hetero)aryl, R3: -CO-R4, -CO-O-R4, etc., R4: alkyl, cycloalkyl, etc., A: CH2, CO, SO2, B: a single bond, etc., D: oxygen, CH2, E: alkylene, alkenylene, n: 1 to 3).

10-(Piperidin o-alkyl)-phenothiazines

Novel 10-(piperidino-alkyl)-phenothiazines of the formula STR1 wherein X is selected from the group consisting of hydrogen, chlorine, --CF3, --OCH3 and SCH3, B and R are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z' is selected from the group consisting of hydrogen and alkyl of 1 to 10 carbon atoms, p is 0 or 1, n is 0, 1 or 2 and A is selected from the group consisting of hydrogen, --COOR2 and --COR1, R2 is linear alkyl of 1 to 15 carbon atoms and R1 is selected from the group consisting of alkyl of 1 to 18 carbon atoms optionally containing a double bond or --O-- and a polymethoxyphenyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, analgesic, spasmolytic and antihistaminic activity and their preparation and novel intermediates.