402563-66-0

Basic information

• Product Name: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-3-[(2-methoxyphenyl)methyl]-4-oxo-, (2R,3S)-
• CAS NO: 402563-66-0
• Molecular Formula: C18H27NO4Si
• Molecular Weight: 349.502
• Mol File: 402563-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-3-[(2-methoxyphenyl)methyl]-4-oxo-, (2R,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-3-[(2-methoxyphenyl)methyl]-4-oxo-, (2R,3S)-(402563-66-0)
• EPA Substance Registry System: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-3-[(2-methoxyphenyl)methyl]-4-oxo-, (2R,3S)-(402563-66-0)

Safety Data

• Hazardous Substances Data: 402563-66-0(Hazardous Substances Data)

Upstream product

• 52289-93-7 o-Methoxybenzyl bromide 
• 82938-50-9 (4R)-1-(tert-butyldimethylsilyl)-2-oxoazetidine-4-carboxylic acid 

Downstream Products

• 256410-42-1 (3S,4S)-4-(4-diphenylmethoxycarbonyl)phenoxy-3-(2-methoxybenzyl)-1-[(R)-(1-phenylpropyl)aminocarbonyl]azetidin-2-one 
• 256410-31-8 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester 
• 256410-41-0 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-propylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-30-7 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 402563-68-2 (3S,4S)-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-3-(2-methoxybenzyl)azetidin-2-one 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h). Copyright