402616-26-6 Usage
Description
(S) FTY720 PHOSPHATE, also known as FTY720-phosphate, is a sphingosine 1-phosphate receptor modulator derived from the active metabolite of FTY720. It is a white solid with significant pharmaceutical applications, particularly in the treatment of autoimmune diseases and modulation of immune cell functions.
Uses
Used in Pharmaceutical Industry:
(S) FTY720 PHOSPHATE is used as an immunomodulatory agent for the treatment of autoimmune diseases, such as experimental autoimmune encephalomyelitis. It functions by inhibiting T cell infiltration, which helps ameliorate the symptoms and progression of the disease.
Used in Neurological Applications:
In the field of neurology, (S) FTY720 PHOSPHATE is used as a therapeutic agent for the management of multiple sclerosis and other demyelinating diseases of the central nervous system. Its ability to modulate immune cell functions makes it a promising candidate for treating these conditions.
Used in Immunological Research:
(S) FTY720 PHOSPHATE is also utilized in immunological research as a tool to study the role of sphingosine 1-phosphate receptors in immune cell signaling and trafficking. This helps researchers better understand the underlying mechanisms of immune responses and develop new therapeutic strategies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 402616-26-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,2,6,1 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 402616-26:
(8*4)+(7*0)+(6*2)+(5*6)+(4*1)+(3*6)+(2*2)+(1*6)=106
106 % 10 = 6
So 402616-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/m0/s1
402616-26-6Relevant articles and documents
Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720
Lu, Xuequan,Bittman, Robert
, p. 825 - 827 (2007/10/03)
The enantiomers of FTY720-phosphate (3) were synthesized via 2-methylene-4-(4-octylphenyl)butan-1-ol (7), 2,3-epoxy alcohol 8, and Δ2-oxazoline 10. These compounds have potential use in the treatment of autoimmune diseases and prevention of kid
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer
Albert, Rainer,Hinterding, Klaus,Brinkmann, Volker,Guerini, Danilo,Müller-Hartwieg, Constanze,Knecht, Helmut,Simeon, Corinne,Streiff, Markus,Wagner, Trixie,Weizenbach, Karl,Zécri, Frédéric,Zollinger, Markus,Cooke, Nigel,Francotte, Eric
, p. 5373 - 5377 (2007/10/03)
In vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically active (S)-configured enantiomer, which was proven by an ex vivo o-phthaldialdehyde derivatization protocol especially elaborated for phosphates of 1. Starting from the prochiral amino alcohol 1, racemic and enantiomerically pure phosphates of 1 were synthesized. Pure enantiomers were obtained after purification of a partially protected key intermediate on an enantioselective support. The absolute stereochemistry was determined by X-ray diffraction.