40273-52-7

Basic information

• Product Name: 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol
• Synonyms: 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol
• CAS NO: 40273-52-7
• Molecular Formula: C₈H₉ClFNO
• Molecular Weight: 189.6145632
• Mol File: 40273-52-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol(40273-52-7)
• EPA Substance Registry System: 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol(40273-52-7)

Safety Data

• Hazardous Substances Data: 40273-52-7(Hazardous Substances Data)

Upstream product

• 17282-04-1 2-chloro-3-fluoropyridine 
• 67-64-1 acetone 

Downstream Products

• 628322-91-8 2-(8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol 
• 882187-82-8 2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile 

Relevant articles and documents

Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation

A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.

IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.