40298-71-3

Basic information

• Product Name: BOC-TYR(2,6-DI-CL-BZL)-OH
• Synonyms: o-[(2,6-dichlorophenyl)methyl]-n-[(1,1-dimethylethoxy)carbonyl]-l-tyrosin;BOC-TYROSINE(2,6-DICHLORO-BZL)-OH;BOC-TYR(CL2-BZL);BOC-TYR(CL2-BZL)-OH;BOC-TYR(2,6-DI-CL-BZL)-OH;BOC-TYR(2,6-CL2-BZL)-OH;BOC-TYR(2,6-DICHLORO-BZL)-OH;BOC-O-(2,6-DICHLOROBENZYL)-L-TYROSINE
• CAS NO: 40298-71-3
• Molecular Formula: C₂₁H₂₃Cl₂NO₅
• Molecular Weight: 440.32
• EINECS: 254-876-6
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 40298-71-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 128-130°C
• Boiling Point: 594°Cat760mmHg
• Flash Point: 313°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• PKA: 2.98±0.10(Predicted)
• BRN: 3573263
• CAS DataBase Reference: BOC-TYR(2,6-DI-CL-BZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-TYR(2,6-DI-CL-BZL)-OH(40298-71-3)
• EPA Substance Registry System: BOC-TYR(2,6-DI-CL-BZL)-OH(40298-71-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 40298-71-3(Hazardous Substances Data)

Usage

Description

BOC-TYR(2,6-DI-CL-BZL)-OH is an amino acid building block that plays a crucial role in the synthesis of peptides. It is characterized by its unique chemical structure, which includes a Boc-protecting group and a 2,6-dichlorobenzyl (D-Cl-Bzl) side chain. This structure allows for efficient and reliable peptide synthesis, making it a valuable component in the pharmaceutical and biotechnology industries.

Uses

Used in Pharmaceutical Industry:
BOC-TYR(2,6-DI-CL-BZL)-OH is used as an amino acid building block for peptide synthesis, which is essential for the development of new peptide-based drugs. The growing peptide drug market demands fast and reliable synthesis methods, and this compound contributes to achieving that goal.
Used in Biotechnology Industry:
BOC-TYR(2,6-DI-CL-BZL)-OH is also used as a key component in the development of biotechnological applications, such as the creation of novel bioactive peptides with specific functions. Its unique structure enables the design of peptides with enhanced properties, such as improved stability, selectivity, and bioavailability, which are crucial for various biotechnological applications.

InChI:InChI=1/C21H23Cl2NO5/c1-21(2,3)29-20(27)24-18(19(25)26)11-13-7-9-14(10-8-13)28-12-15-16(22)5-4-6-17(15)23/h4-10,18H,11-12H2,1-3H3,(H,24,27)(H,25,26)/t18-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40298-69-9 4-(2,6-dichlorobenzyloxy)-L-phenylalanine 
• 85842-19-9 N-tert-Butoxycarbonyl-O-2,6-dichlorbenzyl-(S)-tyrosin Methylester 

Downstream Products

• 101697-62-5 4-ε-2-chlorobenzyloxycarbonyl)-L-tyrosyl(O-2,6-dichlorobenzyl)-L-alanyloxy>-6-mercaptodibenzofuran 
• 119089-47-3 Boc-Tyr(Cl₂-Bzl)-NHNH-Troc 
• 123347-86-4 C₁₀₇H₁₃₁Cl₂N₁₃O₂₀S 
• 127272-73-5 Boc-Tyr(Cl₂Bzl)-Gln-Lys(z)-Arg(Mts)-OMe 
• 60-18-4 L-tyrosine 
• 123196-92-9 Boc-Tyr(Cl₂-Bzl)-OBt 
• 85842-19-9 N-tert-Butoxycarbonyl-O-2,6-dichlorbenzyl-(S)-tyrosin Methylester 
• 161805-77-2 Boc-Tyr(2,6-di-Cl-Bzl)-CH₂Cl 
• 146843-78-9 (S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionylamino}-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionic acid 2-oxo-2-phenyl-ethyl ester 
• 58822-25-6 Leu-enkephalin 
• 79985-48-1 Dynorphin A-(1-11) amide 
• 111857-96-6 DC-32-53 
• 111857-96-6 DC-32-57 
• 111857-96-6 DC-38-64 

Relevant articles and documents

Synthesis and biological activity of N-substituted aminocarbonyl-1,3- dioxolanes as VLA-4 antagonists

A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.

tert-butoxycarbonylation of amino acids and their derivatives: N-tert-butoxycarbonyl-L-phenylalanine

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