403-66-7Relevant articles and documents
Method for synthesizing nitro (hetero) aromatic hydrocarbon
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Paragraph 0082-0084; 0088-0090, (2022/04/08)
The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.
Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3
Zheng, Changge,Jiang, Chao,Huang, Shuai,Zhao, Kui,Fu, Yingying,Ma, Mingyu,Hong, Jianquan
supporting information, p. 6982 - 6986 (2021/09/08)
Herein, we report an indirect trifluoromethylthiolation of sodium arylsulfinates. This transition-metal-free reaction significantly provides an environmentally friendly and practical synthetic method for aryl trifluoromethyl thioethers using commercial Ruppert-Prakash reagent TMSCF3. This approach is also a potential alternative to the current industrial production method owing to facile substrates, excellent functional group compatibility, and operational simplicity.
Synthetic method of aryltrifluoromethyl sulfide
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Paragraph 0040-0044, (2021/06/12)
The invention provides a synthesis method of an aryltrifluoromethyl sulfide compound, which comprises the following steps: mixing aryl halide, silver trifluoromethane mercaptide, a copper salt catalyst, a nitrogen-containing organic ligand and an organic solvent, and stirring at 20-120 DEG C to react for 1-60 hours, so that after the reaction is finished, the aryl trifluoromethyl thioether compound is generated. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, good substrate universality, high yield, suitability for industrial application and the like.