4031-81-6

Basic information

• Product Name: N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE
• Synonyms: N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE;2'-Chloro-5'-nitroacetanilide;2'-Chloro-5'-nitroacetoanilide;Acetamide, N-(2-chloro-5-nitrophenyl)-
• CAS NO: 4031-81-6
• Molecular Formula: C₈H₇ClN₂O₃
• Molecular Weight: 214.61
• Mol File: 4031-81-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391.2°Cat760mmHg
• Flash Point: 190.4°C
• Appearance: /
• Density: 1.466g/cm³
• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(4031-81-6)
• EPA Substance Registry System: N-(2-CHLORO-5-NITROPHENYL)ACETAMIDE(4031-81-6)

Safety Data

• Hazardous Substances Data: 4031-81-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7ClN2O3/c1-5(12)10-8-4-6(11(13)14)2-3-7(8)9/h2-4H,1H3,(H,10,12)

Upstream product

• 533-17-5 N-(2-chlorophenyl)acetamide 
• 64-19-7 acetic acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 75-36-5 acetyl chloride 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 95-51-2 o-chloroaniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 100872-81-9 acetic acid-(5-nitro-2-phenoxy-anilide) 
• 2941-66-4 2-methyl-5-nitrobenzothiazole 
• 200403-70-9 acetic acid-(2-methylsulfanyl-5-nitro-anilide) 
• 453562-68-0 1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone 
• 78228-01-0 2-(methylthio)-5-nitroaniline 
• 2810-45-9 chloro-acetic acid-(N-methyl-3-nitro-anilide) 
• 5367-36-2 4-(N,N-dimethylamino)-3-acetamidonitrobenzene 
• 959855-42-6 2-methyl-1-(2-methylphenyl)-5-nitro-1H-benzimidazole 
• 1219135-11-1 N-(4-chloro-3-acetamido-phenyl)benzenesulfonamide 
• 926208-07-3 N-(4-chloro-3-amino-phenyl)benzenesulfonamide 
• 1219134-64-1 N-[4-chloro-3-(1-methylpiperidin-4-ylamino)phenyl]benzenesulfonamide 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS

The present invention relates to novel aryl sulfonamide amine compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein

A palladium-catalyzed regiospecific synthesis of N-aryl benzimidazoles

(Chemical Equation Presented) Highly tolerated: A catalytic method employing [Pd2(dba)3] and XPhos or RuPhos permits the efficient synthesis of N-aryl benzimidazoles in regioisomerically pure form starting from ortho-halo-anilides (see scheme), and tolerates a wide range of functional groups, dba = trans,trans-dibenzylideneacetone.