40312-16-1

Basic information

• Product Name: N-HYDROXY-3,4-DIMETHOXY-BENZAMIDINE
• Synonyms: N-Hydroxy-3,4-diMethoxybenziMidaMide
• CAS NO: 40312-16-1
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.21
• Mol File: 40312-16-1.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-HYDROXY-3,4-DIMETHOXY-BENZAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HYDROXY-3,4-DIMETHOXY-BENZAMIDINE(40312-16-1)
• EPA Substance Registry System: N-HYDROXY-3,4-DIMETHOXY-BENZAMIDINE(40312-16-1)

Safety Data

• Hazardous Substances Data: 40312-16-1(Hazardous Substances Data)

Upstream product

• 2024-83-1 veratronitrile 
• 621-59-0 isovanillin 
• 52805-46-6 2-methoxy-5-cyanophenol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 2169-98-4 3,4-Dimethoxy-benzaldehyde oxime 

Downstream Products

• 95709-23-2 N-chloroacetoxy-3,4-dimethoxy-benzamidine 
• 95515-26-7 N-(3-chloro-propionyloxy)-3,4-dimethoxy-benzamidine 
• 94297-19-5 [3-(3,4-dimethoxy-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-diethyl-amine 
• 91066-47-6 5-chloromethyl-3-(3,4-dimethoxy-phenyl)-[1,2,4]oxadiazole 
• 421583-83-7 3,5-bis(3,4-dimethoxyphenyl)-1,2,4-oxadiazole 
• 1235444-11-7 N'-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-ylcarbonyloxy)-3,4-dimethoxybenzimidamide 
• 1312793-84-2 tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate 
• 1240179-16-1 3-(3,4-dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,2,4-oxadiazole 
• 340218-52-2 3-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 884637-31-4 3-(3,4-dimethoxyphenyl)-5-(3-methoxyphenyl)-1,2,4-oxadiazole 
• 884627-81-0 3-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 
• 1424313-56-3 2-(3,4-dimethoxyphenyl)-5-oxo-5H-chromeno[4,3-d]pyrimidine-3-oxide 
• 697245-66-2 ethyl 3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxylate 
• 26904-02-9 3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5(4H)-one 

Relevant articles and documents

Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs. Thus, in the present investigation, a novel series of 1,2,4-oxadiazole-

Optimization of the synthesis of het/aryl-amidoximes using an efficient green chemistry

This work focuses on optimizing an efficient green synthesis of arylamidoximes from appropriate nitrile and hydroxylamine hydrochloride in water and triethylamine (1.6 mol equivalent) as a base at room temperature for 6 h. This new green synthetic methodology is compared with previously known methods. The main advantages of this new process reported are good yield, easier work-up and short reaction times. Moreover, some of the synthesized arylamidoximes converted to 1,2,4-oxadiazole derivatives 13a,b and 14via the reaction with (4-acetylphenoxy)acetic acid 12.

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.