4033-42-5

Basic information

• Product Name: AC-LEU-GLY-OH
• Synonyms: ACETYL-L-LEUCYL GLYCINE;AC-LEU-GLY-OH
• CAS NO: 4033-42-5
• Molecular Formula: C10H18N2O4
• Molecular Weight: 230.26
• Mol File: 4033-42-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: AC-LEU-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-LEU-GLY-OH(4033-42-5)
• EPA Substance Registry System: AC-LEU-GLY-OH(4033-42-5)

Safety Data

• Hazardous Substances Data: 4033-42-5(Hazardous Substances Data)

Usage

Description

AC-LEU-GLY-OH is a chemical compound composed of acetyl-leucine and glycine amino acids, linked together with a hydroxyl group at the carboxylic acid end. It is widely used in molecular biology, biochemistry research, pharmaceutical development, and the production of new materials and food additives.

Uses

Used in Molecular Biology and Biochemistry Research:
AC-LEU-GLY-OH is used as a building block for peptide synthesis and as a standard for analyzing the performance of chromatography columns. Its role in these applications is crucial for advancing scientific research and understanding of peptide structures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, AC-LEU-GLY-OH is used as a component in the development of drug candidates, particularly in the design of peptide-based therapeutics. Its versatile nature allows for the creation of potential treatments for various diseases and conditions.
Used in the Development of New Materials:
AC-LEU-GLY-OH is also utilized in the development of new materials, showcasing its potential in various scientific and industrial applications beyond its use in research and pharmaceuticals.
Used in Flavor Enhancers and Food Additives Production:
Furthermore, AC-LEU-GLY-OH serves as a component in the production of flavor enhancers and food additives, contributing to the taste and quality of various food products.

Upstream product

• 909259-49-0 N-acetyl-L-leucylglycine ethyl ester 
• 17554-10-8 Ac-Leu-Gly-OMe 
• 1188-21-2 N-Ac-Leu 

Downstream Products

• 660847-06-3 Ac-Leu-Gly-Lys(Ac)-AMC 
• 1026295-98-6 Ac-Leu-Gly-Lys(trifluroAc)-AMC 

Relevant articles and documents

Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme

The class III lysine deacylases (KDACs), also known as the sirtuins, have emerged as interesting drug targets for therapeutic intervention in a variety of diseases. To gain a deeper understanding of the processes affected by sirtuins, the development of selective small molecule modulators of individual isozymes has been a longstanding goal. Essential for the discovery of novel modulators, however, are good screening protocols and mechanistic insights with regard to the targets in question. We therefore evaluated the activities of the seven human sirtuin hydrolases against a panel of fluorogenic substrates. Both commonly used, commercially available substrates and novel chemotypes designed to address recent developments in the field of lysine post-translational modification were evaluated. Our investigations led to the discovery of two new fluorogenic ε-N-succinyllysine-containing substrates that enable highly efficient and enzyme-economical screening employing sirtuin 5 (SIRT5). Furthermore, optimized protocols for facile kinetic investigations were developed, which should be valuable for enzyme kinetic investigations. Finally, these protocols were applied to a kinetic analysis of the inhibition of SIRT5 by suramin, a potent sirtuin inhibitor previously shown by X-ray crystallography to bind the substrate pocket of the human SIRT5 KDAC enzyme.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.